eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eepd1provided by ZNC
Official Full Name: endonuclease/exonuclease/phosphatase family domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1831
See related: Ensembl:ENSDARG00000071116 AllianceGenome:ZFIN:ZDB-GENE-040426-1831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77395
Summary: Predicted to enable DNA binding activity. Predicted to act upstream of or within DNA repair. Predicted to be active in plasma membrane. Is expressed in yolk syncytial layer. Orthologous to human EEPD1 (endonuclease/exonuclease/phosphatase family domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (11271058..11315215, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (11353060..11397217, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrate that EEPD1 maintains genome stability during embryonic replication stress.
Title: The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endonuclease/exonuclease/phosphatase family domain-containing protein 1

Names: KIAA1706-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205759.1 → NP_991322.1 endonuclease/exonuclease/phosphatase family domain-containing protein 1

See identical proteins and their annotated locations for NP_991322.1

Status: PROVISIONAL

Source sequence(s)

AY422999

UniProtKB/Swiss-Prot

Q6P0E2, Q6TEQ0

Related

ENSDARP00000095703.2, ENSDART00000104933.4

Conserved Domains (2) summary

cd10283
Location:246 → 521

MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like

pfam12836
Location:126 → 182

HHH_3; Helix-hairpin-helix motif