idh1 isocitrate dehydrogenase (NADP(+)) 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: idh1provided by ZNC
Official Full Name: isocitrate dehydrogenase (NADP(+)) 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-1
See related: Ensembl:ENSDARG00000025375 AllianceGenome:ZFIN:ZDB-GENE-031006-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb876; fm90e09; im:7143416; wu:fm90e09
Summary: Predicted to enable isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within hemopoiesis. Predicted to be active in cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including digestive system; ectoderm; mesoderm; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (28104619..28128034)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (28293873..28317288)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
Title: MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
generated a transgenic zebrafish model system for mutations in IDH1 that can be used for functional analysis and drug screening. Our model systems help understand the biology of IDH1 mutations and its role in tumor formation.
Title: IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glyoxylate cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: isocitrate dehydrogenase [NADP] cytoplasmic

Names: isocitrate dehydrogenase 1 (NADP+), soluble

NP_958907.1

EC 1.1.1.42

XP_005167712.1

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201499.1 → NP_958907.1 isocitrate dehydrogenase [NADP] cytoplasmic

See identical proteins and their annotated locations for NP_958907.1

Status: PROVISIONAL

Source sequence(s)

BC046894

UniProtKB/TrEMBL

Q802Y2

Related

ENSDARP00000023774.7, ENSDART00000007789.10

Conserved Domains (1) summary

PTZ00435
Location:15 → 424

PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

28104619..28128034

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167655.5 → XP_005167712.1 isocitrate dehydrogenase [NADP] cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8M2BF40

Conserved Domains (1) summary

PTZ00435
Location:1 → 410

PTZ00435; isocitrate dehydrogenase; Provisional