ptmab prothymosin alpha b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptmabprovided by ZNC
Official Full Name: prothymosin alpha bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8681
See related: Ensembl:ENSDARG00000101766 AllianceGenome:ZFIN:ZDB-GENE-030131-8681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa94b10; wu:fa94b10; zgc:165530
Summary: Predicted to enable histone binding activity. Acts upstream of or within apoptotic process. Located in nucleus. Is expressed in several structures, including central nervous system; fin; pleuroperitoneal region; sensory system; and tail bud. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (5131972..5135125, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336589.1 (34777..37930, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that prothymosin alpha (PTMA) transcripts are expressed in the testis, and localize in meiotic and post-meiotic germ cells, namely spermatocytes and spermatids.
Title: Prothymosin alpha expression and localization during the spermatogenesis of Danio rerio.
Ptmab morphants exhibited growth retardation, bended trunks, and curly tails.
Title: Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prothymosin alpha-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.