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    slc2a3a solute carrier family 2 member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 436916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc2a3aprovided by ZNC
    Official Full Name
    solute carrier family 2 member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-390
    See related
    Ensembl:ENSDARG00000013295 AllianceGenome:ZFIN:ZDB-GENE-040718-390
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    glut3a; slc2a3; zgc:92476; wu:fb92c06
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Acts upstream of or within brain development. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and spinal cord neural tube. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc2a3a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9685209..9712482, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9766287..9794300, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 1a Neighboring gene serine/threonine/tyrosine kinase 1a Neighboring gene uncharacterized LOC137488432 Neighboring gene si:dkey-14o18.2 Neighboring gene calcium channel, voltage-dependent, gamma subunit 6a Neighboring gene uncharacterized LOC108180147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. GLUT3 gene expression is critical for embryonic growth, brain development and survival. Carayannopoulos MO, et al. Mol Genet Metab, 2014 Apr. PMID 24529979, Free PMC Article
    2. Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio). Capiotti KM, et al. Behav Brain Res, 2014 Nov 1. PMID 25157430
    3. Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo. Zheng PP, et al. Ann Neurol, 2010 Dec. PMID 21194153
    4. An Association between Insulin Resistance and Neurodegeneration in Zebrafish Larval Model (Danio rerio). Md Razip NN, et al. Int J Mol Sci, 2022 Jul 27. PMID 35955446, Free PMC Article
    5. Glucose metabolism is required for oocyte maturation of zebrafish. Kang T, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33945997

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 3a
    Names
    solute carrier family 2 (facilitated glucose transporter), member 3
    solute carrier family 2 (facilitated glucose transporter), member 3a
    zglut3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002643.1 → NP_001002643.1  solute carrier family 2, facilitated glucose transporter member 3a

      See identical proteins and their annotated locations for NP_001002643.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076560
      UniProtKB/TrEMBL
      A0A8M2B5Y6, Q6DFZ5
      Related
      ENSDARP00000015253.5, ENSDART00000016197.7
      Conserved Domains (2) summary
      cd06174
      Location:66 → 432
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:18 → 466
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      9685209..9712482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159426.5 → XP_005159483.1  solute carrier family 2, facilitated glucose transporter member 3a isoform X2

      See identical proteins and their annotated locations for XP_005159483.1

      UniProtKB/TrEMBL
      A0A8M2B5Y6, Q6DFZ5
      Related
      ENSDARP00000120492.1, ENSDART00000134816.2
      Conserved Domains (2) summary
      cd06174
      Location:66 → 432
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:18 → 466
      Sugar_tr; Sugar (and other) transporter

    2. XM_005159425.5 → XP_005159482.1  solute carrier family 2, facilitated glucose transporter member 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5Y7
      Conserved Domains (2) summary
      cd06174
      Location:66 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:18 → 500
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version

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