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    pla2g4aa phospholipase A2, group IVAa (cytosolic, calcium-dependent) [ Danio rerio (zebrafish) ]

    Gene ID: 30554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pla2g4aaprovided by ZNC
    Official Full Name
    phospholipase A2, group IVAa (cytosolic, calcium-dependent)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-45
    See related
    Ensembl:ENSDARG00000024546 AllianceGenome:ZFIN:ZDB-GENE-990415-45
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cpla2; pla2g4; PLA2G4A
    Summary
    Enables phospholipase activity. Acts upstream of or within inflammatory response to wounding; ovarian follicle development; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasmic vesicle. Predicted to be active in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in brain; otic vesicle; and ovary. Orthologous to human PLA2G4A (phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pla2g4aa in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20925899..20958510)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21267837..21299300)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene phosducin a Neighboring gene prostaglandin-endoperoxide synthase 2a Neighboring gene actin related protein 2/3 complex, subunit 5A Neighboring gene LYR motif containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ovulation is associated with the LH-dependent induction of pla2g4aa in zebrafish. Tang H, et al. Mol Cell Endocrinol, 2018 Sep 15. PMID 29326060
    2. Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates. Huang Q, et al. Int J Mol Med, 2015 Mar. PMID 25543670, Free PMC Article
    3. Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity. Naini SM, et al. FASEB J, 2016 Mar. PMID 26644349, Free PMC Article
    4. The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. Enyedi B, et al. Cell, 2016 May 19. PMID 27203112, Free PMC Article
    5. Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Huang C, et al. Immunity, 2018 May 15. PMID 29768163, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation.
      Title: Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation.
    2. these findings suggest that pla2g4aa is related to the ovulation process in zebrafish.
      Title: Ovulation is associated with the LH-dependent induction of pla2g4aa in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic phospholipase A2
    Names
    phospholipase A2 group IVA
    NP_571370.1
    XP_068079049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131295.2 → NP_571370.1  cytosolic phospholipase A2

      See identical proteins and their annotated locations for NP_571370.1

      Status: PROVISIONAL

      Source sequence(s)
      U10330
      UniProtKB/Swiss-Prot
      P50392
      UniProtKB/TrEMBL
      B3DFL0
      Related
      ENSDARP00000090686.2, ENSDART00000099913.3
      Conserved Domains (3) summary
      cd07200
      Location:138 → 719
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:13 → 132
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:113 → 658
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      20925899..20958510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222948.1 → XP_068079049.1  cytosolic phospholipase A2 isoform X1

      Related
      ENSDARP00000143653.1, ENSDART00000178880.2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50392.1 GenPept UniProtKB/Swiss-Prot:P50392

    Gene LinkOut

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