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    nav3 neuron navigator 3 [ Danio rerio (zebrafish) ]

    Gene ID: 567779, updated on 9-Dec-2024

    Summary

    Official Symbol
    nav3provided by ZNC
    Official Full Name
    neuron navigator 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021205-1
    See related
    Ensembl:ENSDARG00000005476 AllianceGenome:ZFIN:ZDB-GENE-021205-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb419; wu:fa05f06
    Summary
    Enables actin binding activity. Acts upstream of or within liver morphogenesis and pancreas development. Located in Golgi apparatus; filopodium; and lamellipodium. Is expressed in several structures, including cardiovascular system; digestive system; liver primordium; nervous system; and periderm. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See nav3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20622794..20990445)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (21091822..21269470)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491397 Neighboring gene uncharacterized LOC108179161 Neighboring gene sialic acid-binding Ig-like lectin 14 Neighboring gene uncharacterized LOC137491546 Neighboring gene uncharacterized LOC101884898

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables actin binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in cell projection  
    located_in filopodium PubMed 
    located_in lamellipodium PubMed 
    located_in membrane  
    located_in nuclear outer membrane  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045143.2 → NP_001038608.1  neuron navigator 3

      See identical proteins and their annotated locations for NP_001038608.1

      Status: PROVISIONAL

      Source sequence(s)
      BX511172, BX537169
      UniProtKB/Swiss-Prot
      Q5TZ18
      Related
      ENSDARP00000021413.7, ENSDART00000005847.9
      Conserved Domains (5) summary
      smart00382
      Location:1960 → 2080
      AAA; ATPases associated with a variety of cellular activities
      PHA03249
      Location:896 → 1055
      PHA03249; DNA packaging tegument protein UL25; Provisional
      cd00014
      Location:59 → 160
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl21455
      Location:1963 → 2054
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23720
      Location:1504 → 1575
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20622794..20990445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475116.2 → XP_021330791.1  neuron navigator 3 isoform X17

      UniProtKB/TrEMBL
      A0A8M9PHH5
      Conserved Domains (5) summary
      smart00382
      Location:2008 → 2128
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:21 → 125
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1507 → 1584
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1119 → 1442
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:870 → 1029
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    2. XM_021475117.2 → XP_021330792.1  neuron navigator 3 isoform X17

      UniProtKB/TrEMBL
      A0A8M9PHH5
      Conserved Domains (5) summary
      smart00382
      Location:2008 → 2128
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:21 → 125
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1507 → 1584
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1119 → 1442
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:870 → 1029
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    3. XM_021475105.2 → XP_021330780.1  neuron navigator 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBF3
      Conserved Domains (5) summary
      smart00382
      Location:2076 → 2196
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    4. XM_021475107.2 → XP_021330782.1  neuron navigator 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PHG5
      Conserved Domains (5) summary
      smart00382
      Location:2076 → 2196
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    5. XM_021475114.2 → XP_021330789.1  neuron navigator 3 isoform X11

      UniProtKB/TrEMBL
      A0A8M9Q0Q3
      Conserved Domains (5) summary
      smart00382
      Location:2047 → 2167
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1554 → 1848
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    6. XM_021475115.2 → XP_021330790.1  neuron navigator 3 isoform X12

      UniProtKB/TrEMBL
      A0A8M9QBG6
      Conserved Domains (5) summary
      smart00382
      Location:2047 → 2167
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1554 → 1848
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    7. XM_017355079.3 → XP_017210568.1  neuron navigator 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YX31
    8. XM_021475111.2 → XP_021330786.1  neuron navigator 3 isoform X8

      UniProtKB/TrEMBL
      A0A8M9Q614
      Conserved Domains (6) summary
      smart00382
      Location:2061 → 2181
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1565 → 1877
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    9. XM_068219723.1 → XP_068075824.1  neuron navigator 3 isoform X14

    10. XM_009300421.4 → XP_009298696.1  neuron navigator 3 isoform X16

      UniProtKB/TrEMBL
      A0A8M3B919
      Conserved Domains (5) summary
      smart00382
      Location:2032 → 2152
      AAA; ATPases associated with a variety of cellular activities
      PHA03249
      Location:938 → 1097
      PHA03249; DNA packaging tegument protein UL25; Provisional
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl21455
      Location:2035 → 2126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23720
      Location:1574 → 1646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    11. XM_021475106.2 → XP_021330781.1  neuron navigator 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q610
      Conserved Domains (6) summary
      smart00382
      Location:2075 → 2195
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1554 → 1876
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    12. XM_021475109.2 → XP_021330784.1  neuron navigator 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q0P5
      Conserved Domains (5) summary
      smart00382
      Location:2068 → 2188
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    13. XM_068219722.1 → XP_068075823.1  neuron navigator 3 isoform X13

    14. XM_021475112.2 → XP_021330787.1  neuron navigator 3 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PHG9
      Conserved Domains (6) summary
      smart00382
      Location:2060 → 2180
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1575 → 1652
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1565 → 1876
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    15. XM_009300420.4 → XP_009298695.1  neuron navigator 3 isoform X15

      UniProtKB/TrEMBL
      A0A8M3ARI4
      Conserved Domains (5) summary
      smart00382
      Location:2031 → 2151
      AAA; ATPases associated with a variety of cellular activities
      PHA03249
      Location:938 → 1097
      PHA03249; DNA packaging tegument protein UL25; Provisional
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl21455
      Location:2034 → 2125
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23720
      Location:1574 → 1646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    16. XM_009300424.4 → XP_009298699.1  neuron navigator 3 isoform X21

      UniProtKB/TrEMBL
      A0A8M3ARS0
      Conserved Domains (5) summary
      smart00382
      Location:2031 → 2151
      AAA; ATPases associated with a variety of cellular activities
      PHA03249
      Location:938 → 1097
      PHA03249; DNA packaging tegument protein UL25; Provisional
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl21455
      Location:2034 → 2125
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23720
      Location:1574 → 1646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    17. XM_021475108.2 → XP_021330783.1  neuron navigator 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PUP3
      Conserved Domains (5) summary
      smart00382
      Location:2069 → 2189
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1568 → 1645
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1187 → 1510
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:938 → 1097
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    18. XM_021475110.2 → XP_021330785.1  neuron navigator 3 isoform X7

      UniProtKB/TrEMBL
      A0A8M9QBF8
      Conserved Domains (4) summary
      smart00382
      Location:2067 → 2187
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1566 → 1643
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1178 → 1501
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    19. XM_021475113.2 → XP_021330788.1  neuron navigator 3 isoform X10

      UniProtKB/TrEMBL
      A0A8M9PUQ1
      Conserved Domains (5) summary
      smart00382
      Location:2053 → 2173
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:92 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:1552 → 1629
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:1164 → 1487
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:915 → 1074
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
    20. XM_021475118.2 → XP_021330793.1  neuron navigator 3 isoform X18

      UniProtKB/TrEMBL
      A0A8M9PUQ7
      Conserved Domains (5) summary
      smart00382
      Location:1879 → 1999
      AAA; ATPases associated with a variety of cellular activities
      TIGR04211
      Location:1378 → 1455
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:990 → 1313
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:741 → 900
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
      cl28482
      Location:1848 → 1900
      Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]
    21. XM_021475119.1 → XP_021330794.1  neuron navigator 3 isoform X19

      UniProtKB/TrEMBL
      A0A8M9Q0Q8
      Conserved Domains (5) summary
      smart00382
      Location:1866 → 1986
      AAA; ATPases associated with a variety of cellular activities
      TIGR04211
      Location:1365 → 1442
      SH3_and_anchor; SH3 domain protein
      cl25496
      Location:977 → 1300
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl27999
      Location:728 → 887
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
      cl28482
      Location:1835 → 1887
      Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]
    22. XM_021475120.2 → XP_021330795.1  neuron navigator 3 isoform X20

      UniProtKB/TrEMBL
      A0A8M9QBH1
      Conserved Domains (6) summary
      smart00382
      Location:1582 → 1702
      AAA; ATPases associated with a variety of cellular activities
      cl25496
      Location:693 → 1016
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1060 → 1383
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27403
      Location:1061 → 1161
      zf-RING_7; C4-type zinc ribbon domain
      cl27999
      Location:444 → 603
      Herpes_pp85; Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
      cl28482
      Location:1551 → 1603
      Pgk2; 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]
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