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    adam10a ADAM metallopeptidase domain 10a [ Danio rerio (zebrafish) ]

    Gene ID: 566044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adam10aprovided by ZNC
    Official Full Name
    ADAM metallopeptidase domain 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040917-2
    See related
    Ensembl:ENSDARG00000053468 AllianceGenome:ZFIN:ZDB-GENE-040917-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    adam10; wu:fc03d12
    Summary
    Predicted to enable metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adam10a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30409071..30492030, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30137916..30220894, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene aquaporin 9b Neighboring gene lipase, hepatic a Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene SAFB-like, transcription modulator Neighboring gene ring finger protein 111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
    2. The N-glycome regulates the endothelial-to-hematopoietic transition. Kasper DM, et al. Science, 2020 Dec 4. PMID 33273096, Free PMC Article
    3. A novel perivascular cell population in the zebrafish brain. Venero Galanternik M, et al. Elife, 2017 Apr 11. PMID 28395729, Free PMC Article
    4. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
    5. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    a disintegrin and metalloprotease domain 10a
    NP_001152786.2
    NP_001417916.1
    XP_005168954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159314.2 → NP_001152786.2  disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL935053, BX957301
      UniProtKB/TrEMBL
      A0A0R4IVX1, A0A8M1NSP3
      Related
      ENSDARP00000141214.2, ENSDART00000162705.2

    2. NM_001430987.1 → NP_001417916.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL935053, BX957301
      UniProtKB/TrEMBL
      A0A0R4IVX1, A0A1D5NT24, A0A8M1NSP3, A0A8M2BG63
      Related
      ENSDARP00000142998.1, ENSDART00000173954.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      30409071..30492030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168897.5 → XP_005168954.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IVX1, A0A8M1NSP3, A0A8M2BGT1, F1RA88
      Related
      ENSDARP00000090413.6, ENSDART00000099639.8
      Conserved Domains (4) summary
      smart00050
      Location:472 → 558
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:226 → 465
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:54 → 151
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:246 → 451
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    Nucleotide Protein Strain
    Heading Accession and Version

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