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    phc1 polyhomeotic homolog 1 [ Danio rerio (zebrafish) ]

    Gene ID: 403008, updated on 9-Dec-2024

    Summary

    Official Symbol
    phc1provided by ZNC
    Official Full Name
    polyhomeotic homolog 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081022-39
    See related
    Ensembl:ENSDARG00000002971 AllianceGenome:ZFIN:ZDB-GENE-081022-39
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ph1; zgc:193796
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to human PHC1 (polyhomeotic homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See phc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31942561..31960344)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31988508..32006317)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein-like Neighboring gene ribosomal protein S9 Neighboring gene uncharacterized LOC108179621 Neighboring gene serine/threonine/tyrosine kinase 1b Neighboring gene glutathione S-transferase kappa 1 Neighboring gene glutathione S-transferase kappa 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    polyhomeotic-like protein 1
    Names
    polyhomeotic Ph1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205707.1NP_991270.1  polyhomeotic-like protein 1

      See identical proteins and their annotated locations for NP_991270.1

      Status: PROVISIONAL

      Source sequence(s)
      AB064939
      UniProtKB/TrEMBL
      Q7T2Y0
      Conserved Domains (3) summary
      cd09577
      Location:760827
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      smart00454
      Location:761827
      SAM; Sterile alpha motif
      pfam16616
      Location:689758
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      31942561..31960344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158338.5XP_005158395.1  polyhomeotic-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B597, E7F4T8
      Related
      ENSDARP00000058495.6, ENSDART00000058496.7
      Conserved Domains (3) summary
      cd09577
      Location:834901
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      smart00454
      Location:835901
      SAM; Sterile alpha motif
      pfam16616
      Location:763832
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    2. XM_005158339.5XP_005158396.1  polyhomeotic-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B579
      Conserved Domains (3) summary
      cd09577
      Location:822889
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      smart00454
      Location:823889
      SAM; Sterile alpha motif
      pfam16616
      Location:751820
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2