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    st14a ST14 transmembrane serine protease matriptase a [ Danio rerio (zebrafish) ]

    Gene ID: 678603, updated on 27-Dec-2024

    Summary

    Official Symbol
    st14aprovided by ZNC
    Official Full Name
    ST14 transmembrane serine protease matriptase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6496
    See related
    Ensembl:ENSDARG00000061173 AllianceGenome:ZFIN:ZDB-GENE-030131-6496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    st14; mat1a; wu:fi41g07; wu:fl72f01; zgc:136950; zgc:152656; zgc:152657
    Summary
    Enables peptidase activity. Involved in protein processing. Acts upstream of or within cell aggregation; epidermis development; and morphogenesis of an epithelium. Predicted to be located in membrane. Is expressed in epidermis; gut; lateral line primordium; otic vesicle; and primitive olfactory epithelium. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See st14a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44532336..44564752)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44538750..44571298)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 10 Neighboring gene amyloid beta (A4) precursor-like protein 2 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene sprouty related EVH1 domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC136950, MGC152656, MGC152657, MGC192760

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ST14 transmembrane serine protease matriptase a
    Names
    epithin
    matriptase 1a
    suppression of tumorigenicity 14 (colon carcinoma) a
    suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
    suppression of tumorigenicity 14a
    NP_001035441.2
    XP_005159306.1
    XP_021323377.1
    XP_068070938.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040351.1NP_001035441.2  ST14 transmembrane serine protease matriptase a

      Status: PROVISIONAL

      Source sequence(s)
      BC115342
      UniProtKB/TrEMBL
      A0A8M1N8U6, Q1RLP8
      Related
      ENSDARP00000081386.5, ENSDART00000086952.7
      Conserved Domains (5) summary
      smart00020
      Location:596828
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:329431
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:510544
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:597831
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:77168
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44532336..44564752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159249.4XP_005159306.1  ST14 transmembrane serine protease matriptase a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM95, A5PMY0, F1QJS6, Q1RLP8
      Related
      ENSDARP00000111652.2, ENSDART00000121994.3
      Conserved Domains (4) summary
      cd00041
      Location:329431
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:510544
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:597831
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:77160
      SEA; SEA domain
    2. XM_068214837.1XP_068070938.1  ST14 transmembrane serine protease matriptase a isoform X2

      UniProtKB/TrEMBL
      A0A8M9P160, Q1RLP8
    3. XM_021467702.2XP_021323377.1  ST14 transmembrane serine protease matriptase a isoform X2

      UniProtKB/TrEMBL
      A0A8M9P160, Q1RLP8
      Conserved Domains (4) summary
      cd00041
      Location:328430
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:509543
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:596830
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:77160
      SEA; SEA domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077278.1: Suppressed sequence

      Description
      NM_001077278.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.