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    dcst2 DC-STAMP domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 556296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dcst2provided by ZNC
    Official Full Name
    DC-STAMP domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070809-6
    See related
    Ensembl:ENSDARG00000088693 AllianceGenome:ZFIN:ZDB-GENE-070809-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within positive regulation of fertilization and regulation of fusion of sperm to egg plasma membrane. Predicted to be located in membrane. Is expressed in sperm. Orthologous to human DCST2 (DC-STAMP domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dcst2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (28727339..28754079)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (28802786..28819454)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene DC-STAMP domain containing 1 Neighboring gene uncharacterized LOC137487911 Neighboring gene S100 calcium binding protein V1 Neighboring gene tripartite motif containing 33, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Sperm Protein Spaca6 is Essential for Fertilization in Zebrafish. Binner MI, et al. Front Cell Dev Biol, 2021. PMID 35047514, Free PMC Article
    2. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Noda T, et al. Commun Biol, 2022 Apr 7. PMID 35393517, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
      Title: Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of fertilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of fusion of sperm to egg plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DC-STAMP domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366341.1 → NP_001353270.1  DC-STAMP domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      CR388365
      UniProtKB/TrEMBL
      A0A8M6Z1B9
      Related
      ENSDARP00000124494.1, ENSDART00000149753.3
      Conserved Domains (2) summary
      pfam07782
      Location:355 → 545
      DC_STAMP; DC-STAMP-like protein
      cl09913
      Location:277 → 359
      Csn2_like; CRISPR/Cas system-associated protein Csn2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      28727339..28754079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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