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    dachb dachshund b [ Danio rerio (zebrafish) ]

    Gene ID: 192122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dachbprovided by ZNC
    Official Full Name
    dachshund bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020402-4
    See related
    Ensembl:ENSDARG00000034785 AllianceGenome:ZFIN:ZDB-GENE-020402-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136530
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within inner ear development and type B pancreatic cell development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; pectoral fin musculature; posterior neural tube; and spinal cord neural rod. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dachb in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (10378706..10448630)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (9694556..9764524)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b Neighboring gene FERM domain-containing protein 7 Neighboring gene canopy FGF signaling regulator 3 Neighboring gene transient receptor potential cation channel, subfamily C, member 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds. Hammond KL, et al. Mech Dev, 2002 Mar. PMID 11850192
    2. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Iglesias AI, et al. Hum Mol Genet, 2014 Mar 1. PMID 24150847
    3. The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. Bricaud O, et al. J Neurosci, 2006 Oct 11. PMID 17035528, Free PMC Article
    4. The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Trivellin G, et al. Mol Cell Endocrinol, 2021 Jan 15. PMID 33248229, Free PMC Article
    5. Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Jędrychowska J, et al. Dev Biol, 2024 Sep. PMID 38492873

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds
      Title: Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136530

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dachshund b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152956.2 → NP_694488.2  dachshund b

      Status: VALIDATED

      Source sequence(s)
      AL935188
      UniProtKB/TrEMBL
      A0A8M1P7P0, F1R4Z6
      Related
      ENSDARP00000046282.6, ENSDART00000046283.8
      Conserved Domains (2) summary
      pfam02437
      Location:48 → 145
      Ski_Sno; SKI/SNO/DAC family
      pfam13863
      Location:437 → 524
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      10378706..10448630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305776.4 → XP_009304051.1  dachshund b isoform X1

      UniProtKB/TrEMBL
      A0A8M3B3U2
      Conserved Domains (2) summary
      pfam02437
      Location:48 → 145
      Ski_Sno; SKI/SNO/DAC family
      pfam13863
      Location:436 → 523
      DUF4200; Domain of unknown function (DUF4200)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394462.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      59219..129141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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