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    hnf1bb HNF1 homeobox Bb [ Danio rerio (zebrafish) ]

    Gene ID: 324283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnf1bbprovided by ZNC
    Official Full Name
    HNF1 homeobox Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3003
    See related
    Ensembl:ENSDARG00000022295 AllianceGenome:ZFIN:ZDB-GENE-030131-3003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    HNF1g; hnf1bl; hnf1gamma; wu:fc23f06
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification involved in pronephros development. Predicted to be active in nucleus. Is expressed in intermediate mesoderm; pronephros; and rhombomere 5. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hnf1bb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (38817838..38840269)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (38770215..38792767)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene RAB24, member RAS oncogene family Neighboring gene HEAT repeat containing 6 Neighboring gene toll-like receptor 22 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish. Sander V, et al. Chem Commun (Camb), 2015. PMID 25407666
    2. hnf1b genes in zebrafish hindbrain development. Choe SK, et al. Zebrafish, 2008 Sep. PMID 18945197, Free PMC Article
    3. Grouper tshβ promoter-driven transgenic zebrafish marks proximal kidney tubule development. Wang Y, et al. PLoS One, 2014. PMID 24905828, Free PMC Article
    4. Transcriptional profiling of the zebrafish proximal tubule. Sander V, et al. Am J Physiol Renal Physiol, 2019 Aug 1. PMID 31188030
    5. Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Wingert RA, et al. Dev Dyn, 2011 Aug. PMID 21761484, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 1-beta-B
    Names
    liver-enriched atypical homeobox-containing transcription factor
    transcription factor 2 like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194372.3 → NP_919353.1  hepatocyte nuclear factor 1-beta-B

      See identical proteins and their annotated locations for NP_919353.1

      Status: VALIDATED

      Source sequence(s)
      CU694492, LO018189
      UniProtKB/Swiss-Prot
      Q8UW00
      Related
      ENSDARP00000143259.1, ENSDART00000177616.2
      Conserved Domains (3) summary
      cd00086
      Location:245 → 318
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:327 → 525
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:12 → 182
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      38817838..38840269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215784.1 → XP_068071885.1  hepatocyte nuclear factor 1-beta-B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8UW00.1 GenPept UniProtKB/Swiss-Prot:Q8UW00

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