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    tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [ Danio rerio (zebrafish) ]

    Gene ID: 407712, updated on 22-Dec-2024

    Summary

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    Official Symbol
    tph2provided by ZNC
    Official Full Name
    tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040624-4
    See related
    Ensembl:ENSDARG00000057239 AllianceGenome:ZFIN:ZDB-GENE-040624-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tphR; wu:fq15a04
    Summary
    Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tph2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16989764..17001056, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17000698..17011990, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438117 Neighboring gene si:ch211-218c6.8 Neighboring gene TBC1 domain family, member 15 Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene hyaluronan synthase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Cheng RK, et al. Sci Rep, 2016 Feb 12. PMID 26868164, Free PMC Article
    2. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Wang F, et al. Chemosphere, 2018 May. PMID 29421749, Free PMC Article
    3. The dorsal raphe modulates sensory responsiveness during arousal in zebrafish. Yokogawa T, et al. J Neurosci, 2012 Oct 24. PMID 23100441, Free PMC Article
    4. The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Agetsuma M, et al. Nat Neurosci, 2010 Nov. PMID 20935642
    5. The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning. Kawashima T, et al. Cell, 2016 Nov 3. PMID 27881303

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.
      Title: Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness.
    2. tphR is expressed in serotonergic raphe neurons, similar to tph genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin
      Title: Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan 5-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan 5-hydroxylase 2
    Names
    tph2a
    tryptophan hydroxylase R
    NP_001296997.1
    NP_999960.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310068.1 → NP_001296997.1  tryptophan 5-hydroxylase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX950194, EB870154
      UniProtKB/TrEMBL
      A0A8M1P7E6
      Related
      ENSDARP00000074283.4, ENSDART00000079832.6
      Conserved Domains (3) summary
      TIGR01270
      Location:84 → 541
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:108 → 180
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:208 → 537
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    2. NM_214795.2 → NP_999960.2  tryptophan 5-hydroxylase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1
      Source sequence(s)
      BX950194, EB870154
      UniProtKB/TrEMBL
      A0A8M1PK25, Q1LUE3
      Related
      ENSDARP00000102919.3, ENSDART00000112627.5
      Conserved Domains (3) summary
      TIGR01270
      Location:11 → 468
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:35 → 107
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:135 → 464
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      16989764..17001056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      192739..203487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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