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    glyctk glycerate kinase [ Danio rerio (zebrafish) ]

    Gene ID: 570678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glyctkprovided by ZNC
    Official Full Name
    glycerate kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-308
    See related
    Ensembl:ENSDARG00000060120 AllianceGenome:ZFIN:ZDB-GENE-061013-308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153346
    Summary
    Predicted to enable glycerate kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See glyctk in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (43019759..43072879, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (43022223..43031368, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 Neighboring gene si:ch73-361p23.3 Neighboring gene T cell leukemia translocation altered Neighboring gene leucine rich repeat neuronal 1 Neighboring gene uncharacterized LOC108190497

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153346

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycerate kinase
    NP_001070856.2
    NP_001303888.1
    XP_005166117.1
    XP_005166119.1
    XP_021332594.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077388.2 → NP_001070856.2  glycerate kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CU856681, EH584158, EH598128
      UniProtKB/Swiss-Prot
      Q08BL7
      UniProtKB/TrEMBL
      A0A8M1NBF1, F8W2P6
      Related
      ENSDARP00000124654.1, ENSDART00000149092.3
      Conserved Domains (1) summary
      cl26100
      Location:29 → 522
      DUF4147; Domain of unknown function (DUF4147)

    2. NM_001316959.1 → NP_001303888.1  glycerate kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CU856681, EH584158, EH598128
      UniProtKB/Swiss-Prot
      Q08BL7
      UniProtKB/TrEMBL
      A0A8M1NBF1, F8W2P6
      Related
      ENSDARP00000134677.1, ENSDART00000161722.2
      Conserved Domains (1) summary
      cl26100
      Location:29 → 522
      DUF4147; Domain of unknown function (DUF4147)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      43019759..43072879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476919.2 → XP_021332594.1  glycerate kinase isoform X1

      UniProtKB/Swiss-Prot
      Q08BL7
      UniProtKB/TrEMBL
      A0A8M1NBF1, F8W2P6
      Conserved Domains (1) summary
      cl26100
      Location:29 → 522
      DUF4147; Domain of unknown function (DUF4147)

    2. XM_005166062.4 → XP_005166119.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_005166119.1

      UniProtKB/Swiss-Prot
      Q08BL7
      UniProtKB/TrEMBL
      A0A8M1NBF1, F8W2P6
      Conserved Domains (1) summary
      cl26100
      Location:29 → 522
      DUF4147; Domain of unknown function (DUF4147)

    3. XM_005166060.5 → XP_005166117.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_005166117.1

      UniProtKB/Swiss-Prot
      Q08BL7
      UniProtKB/TrEMBL
      A0A8M1NBF1, F8W2P6
      Conserved Domains (1) summary
      cl26100
      Location:29 → 522
      DUF4147; Domain of unknown function (DUF4147)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08BL7.1 GenPept UniProtKB/Swiss-Prot:Q08BL7

    Gene LinkOut

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