rab5b RAB5B, member RAS oncogene family [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab5bprovided by ZNC
Official Full Name: RAB5B, member RAS oncogene familyprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2593
See related: Ensembl:ENSDARG00000016059 AllianceGenome:ZFIN:ZDB-GENE-040426-2593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76978
Summary: Predicted to enable GTPase activity. Predicted to be involved in endocytosis and intracellular protein transport. Predicted to be located in phagocytic vesicle membrane. Predicted to be active in early endosome; endocytic vesicle; and plasma membrane. Is expressed in pronephric duct; pronephric mesoderm; pronephros; telencephalon; and yolk syncytial layer. Orthologous to human RAB5B (RAB5B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (27750515..27775208)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (27939835..27952587)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-5B

Names: RAB5A member RAS oncogene family

NP_998050.1

EC 3.6.5.2

XP_068079458.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212885.1 → NP_998050.1 ras-related protein Rab-5B

See identical proteins and their annotated locations for NP_998050.1

Status: PROVISIONAL

Source sequence(s)

BC066634

UniProtKB/TrEMBL

A0A8M1PMP7, Q6NYD6

Related

ENSDARP00000004030.8, ENSDART00000021065.10

Conserved Domains (2) summary

cd01860
Location:20 → 182

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:22 → 183

Ras; Ras family