rnf41 ring finger protein 41 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rnf41provided by ZNC
Official Full Name: ring finger protein 41provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2920
See related: Ensembl:ENSDARG00000036831 AllianceGenome:ZFIN:ZDB-GENE-040426-2920
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55389; wu:fi13f07; wu:fi25b06
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within melanocyte differentiation. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including germ ring; muscle; nervous system; neural crest; and optic cup. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (32308814..32334208, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (32382283..32407677, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nrdp1 is associated with differentiation process of the melanocyte lineage by regulating Erbb3b, an Erbb signaling molecule along zebrafish embryogenesis.
Title: Nrdp1 governs differentiation of the melanocyte lineage via Erbb3b signaling in the zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fi13f07.x1 (e-PCR)
- UniSTS:196827

fi25b06.x1 (e-PCR)
- UniSTS:197098

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NRDP1

Names: RING-type E3 ubiquitin transferase NRDP1

NP_998681.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213516.1 → NP_998681.1 E3 ubiquitin-protein ligase NRDP1

See identical proteins and their annotated locations for NP_998681.1

Status: PROVISIONAL

Source sequence(s)

BC045329

UniProtKB/Swiss-Prot

Q7ZW16

Related

ENSDARP00000053471.4, ENSDART00000053472.5

Conserved Domains (2) summary

cd00162
Location:18 → 55

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting