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    fignl1 fidgetin-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 569539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fignl1provided by ZNC
    Official Full Name
    fidgetin-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1862
    See related
    Ensembl:ENSDARG00000016427 AllianceGenome:ZFIN:ZDB-GENE-030131-1862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb82h05; wu:fb82h05; wu:fj99a11; zgc:193664
    Summary
    Enables protein-macromolecule adaptor activity. Acts upstream of or within microtubule cytoskeleton organization. Predicted to be located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including nervous system; solid lens vesicle; swim bladder bud; tail bud; and vertical myoseptum. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fignl1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15933142..15943934)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15802143..15812942)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1a Neighboring gene si:ch211-57f7.7 Neighboring gene uncharacterized LOC101883107 Neighboring gene tubulin tyrosine ligase Neighboring gene IKAROS family zinc finger 1 (Ikaros) Neighboring gene uncharacterized LOC137487381 Neighboring gene sperm microtubule inner protein 7 Neighboring gene uncharacterized LOC137487380

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics. Fassier C, et al. J Cell Biol, 2018 May 7. PMID 29535193, Free PMC Article
    2. Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein. Zhao X, et al. Cell Cycle, 2016 Sep. PMID 27384458, Free PMC Article
    3. FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation. Atkins M, et al. J Cell Biol, 2019 Oct 7. PMID 31541015, Free PMC Article
    4. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. Miyake A, et al. PLoS One, 2017. PMID 28448525, Free PMC Article
    5. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study thus pinpoints Fignl1 as a multifaceted key player in MT remodeling underlying motor circuit connectivity.
      Title: Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics.
    2. FIGL-1 is a new centrosomal protein and inhibits ciliogenesis.
      Title: Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fidgetin-like protein 1
    NP_001122223.1
    XP_005156740.1
    XP_005156741.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128751.1 → NP_001122223.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001122223.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162519
      UniProtKB/TrEMBL
      A0A8M2B2R1, B3DGU1
      Related
      ENSDARP00000017944.6, ENSDART00000016294.8
      Conserved Domains (3) summary
      smart00382
      Location:420 → 556
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:424 → 554
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:610 → 658
      Vps4_C; Vps4 C terminal oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15933142..15943934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156684.5 → XP_005156741.1  fidgetin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005156741.1

      UniProtKB/TrEMBL
      A0A8M2B2R1, B3DGU1
      Conserved Domains (3) summary
      smart00382
      Location:420 → 556
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:424 → 554
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:610 → 658
      Vps4_C; Vps4 C terminal oligomerization domain

    2. XM_005156683.5 → XP_005156740.1  fidgetin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005156740.1

      UniProtKB/TrEMBL
      A0A8M2B2R1, B3DGU1
      Related
      ENSDARP00000117905.1, ENSDART00000131390.2
      Conserved Domains (3) summary
      smart00382
      Location:420 → 556
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:424 → 554
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:610 → 658
      Vps4_C; Vps4 C terminal oligomerization domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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