ELF4 EARLY FLOWERING-like protein (DUF1313) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ELF4
Official Full Name: EARLY FLOWERING-like protein (DUF1313)
Primary source: TAIR:AT2G40080
Locus tag: AT2G40080
See related: Araport:AT2G40080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EARLY FLOWERING 4; T28M21.24; T28M21_24
Summary: Encodes a novel nuclear 111 amino-acid phytochrome-regulated component of a negative feedback loop involving the circadian clock central oscillator components CCA1 and LHY. ELF4 is necessary for light-induced expression of both CCA1 and LHY, and conversely, CCA1 and LHY act negatively on light-induced ELF4 expression. ELF4 promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. It is involved in the phyB-mediated constant red light induced seedling de-etiolation process and may function to coregulate the expression of a subset of phyB-regulated genes.
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Genomic context

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See ELF4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (16734294..16734953, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis.
Title: Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis.
Data identified proteins that associate with the evening complex composed of EARLY FLOWERING 4 (ELF4), EARLY FLOWERING 3 (ELF3), and LUX ARRHYTHMO (LUX).
Title: Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry.
The evening loop of the circadian clock is represented by ELF3 and ELF4.
Title: A Bayesian approach for parameter estimation in the extended clock gene circuit of Arabidopsis thaliana.
GI and ELF4 have differentially dominant influences on circadian physiological outputs at dusk and dawn, respectively.
Title: GIGANTEA and EARLY FLOWERING 4 in Arabidopsis exhibit differential phase-specific genetic influences over a diurnal cycle.
The ELF4 recognition site of ELF3 is required for sustaining circadian rhythm. ELF3 and ELF4 directly repress the morning clock gene PPR9.
Title: EARLY FLOWERING4 recruitment of EARLY FLOWERING3 in the nucleus sustains the Arabidopsis circadian clock.
identification of a protein complex composed of the proteins encoded by EARLY FLOWERING 3 (ELF3), ELF4 and the transcription-factor-encoding gene LUX ARRHYTHMO (LUX; also known as PHYTOCLOCK 1)--that directly regulates plant growth
Title: The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth.
ELF4 is required to regulate the expression of CCA1 and TOC1 and can be considered a component of the central CCA1/LHY-TOC1 feedback loop in the plant circadian clock.
Title: ELF4 is required for oscillatory properties of the circadian clock.
The function of ELF3 and ELF4 in their light-regulated expression associated with CCA1, LHY, and TOC1 as part of the central oscillator of the circadian clock in Arabidopsis is reported.
Title: ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129566.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoperiodism	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within photoperiodism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within red or far-red light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to red light	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: EARLY FLOWERING-like protein (DUF1313)

NP_565922.1

EARLY FLOWERING 4 (ELF4); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1313 (InterPro:IPR009741); BEST Arabidopsis thaliana protein match is: ELF4-like 1 (TAIR:AT2G29950.1); Has 150 Blast hits to 149 proteins in 35 species: Archae - 0; Bacteria - 3; Metazoa - 0; Fungi - 0; Plants - 146; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16734294..16734953 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129566.2 → NP_565922.1 EARLY FLOWERING-like protein (DUF1313) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04211

UniProtKB/TrEMBL

A0A178VRH7, A0A5S9X658, A0A654F1T6

Conserved Domains (1) summary

pfam07011
Location:20 → 95

DUF1313; Protein of unknown function (DUF1313)