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    HB4 homeobox-leucine zipper protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819100, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB4
    Official Full Name
    homeobox-leucine zipper protein 4
    Primary source
    TAIR:AT2G44910
    Locus tag
    AT2G44910
    See related
    Araport:AT2G44910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HOMEOBOX-LEUCINE ZIPPER PROTEIN 4; ATHB-4; ATHB4; homeobox-leucine zipper protein 4; T13E15.8
    Summary
    Encodes a homeodomain protein whose expression displays a dependence on phyB for both red and far-red light response. Also involved in the shade avoidance syndrome.
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    Genomic context

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    See HB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (18517656..18519731, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ARABIDILLO-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A non-DNA-binding activity for the ATHB4 transcription factor in the control of vegetation proximity. Gallemí M, et al. New Phytol, 2017 Nov. PMID 28805249
    2. ATHB4, a regulator of shade avoidance, modulates hormone response in Arabidopsis seedlings. Sorin C, et al. Plant J, 2009 Jul. PMID 19392702
    3. Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function. Turchi L, et al. Development, 2013 May. PMID 23578926
    4. ATHB4 and HAT3, two class II HD-ZIP transcription factors, control leaf development in Arabidopsis. Bou-Torrent J, et al. Plant Signal Behav, 2012 Nov. PMID 22918502, Free PMC Article
    5. The Arabidopsis Athb-2 and -4 genes are strongly induced by far-red-rich light. Carabelli M, et al. Plant J, 1993 Sep. PMID 8106086

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HB4 works as a transcriptional cofactor in the regulation of the control of vegetation proximity.
      Title: A non-DNA-binding activity for the ATHB4 transcription factor in the control of vegetation proximity.
    2. ATHB4 and HAT3, two class II HD-ZIP transcription factors, control leaf development in Arabidopsis.
      Title: ATHB4 and HAT3, two class II HD-ZIP transcription factors, control leaf development in Arabidopsis.
    3. a genetic system consisting of HD-Zip II and HD-Zip III genes (ATHB2, ATHB4) cooperates in establishing bilateral symmetry and patterning along the adaxial-abaxial axis in the embryo as well as in controlling SAM activity
      Title: Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function.
    4. ATHB4 is a novel regulatory component of the shade avoidance syndrome transcriptional network which controls auxin, brassinosteroid and gibberellin-mediated growth.
      Title: ATHB4, a regulator of shade avoidance, modulates hormone response in Arabidopsis seedlings.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130055.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hormone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    homeobox-leucine zipper protein 4
    NP_182018.1
    • homeobox-leucine zipper protein 4 (HB4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to hormone stimulus, shade avoidance, regulation of transcription, DNA-dependent, response to far red light, regulation of gene-specific transcription; LOCATED IN: nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), HD-ZIP protein, N-terminal (InterPro:IPR006712), Homeodomain-like (InterPro:IPR009057), Leucine zipper, homeobox-associated (InterPro:IPR003106), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox-leucine zipper protein 3 (TAIR:AT3G60390.1); Has 8851 Blast hits to 8789 proteins in 513 species: Archae - 0; Bacteria - 2; Metazoa - 6351; Fungi - 241; Plants - 2079; Viruses - 4; Other Eukaryotes - 174 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18517656..18519731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130055.2 → NP_182018.1  homeobox-leucine zipper protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92953, Q546G8
      UniProtKB/TrEMBL
      A0A178VMQ6, A0A384LKZ1, A0A5S9X735, A0A654F399, C0SV86
      Conserved Domains (3) summary
      smart00340
      Location:218 → 261
      HALZ; homeobox associated leucin zipper
      pfam00046
      Location:166 → 216
      Homeobox; Homeobox domain
      pfam04618
      Location:8 → 124
      HD-ZIP_N; HD-ZIP protein N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92953.1

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