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    TPS8 trehalose-6-phosphatase synthase S8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843365, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPS8
    Official Full Name
    trehalose-6-phosphatase synthase S8
    Primary source
    TAIR:AT1G70290
    Locus tag
    AT1G70290
    See related
    Araport:AT1G70290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTPS8; ATTPSC; F17O7.18; F17O7_18; trehalose-6-phosphatase synthase S8
    Summary
    Encodes an enzyme putatively involved in trehalose biosynthesis. Though the protein has both trehalose-6-phosphate synthase (TPS)-like and trehalose-6-phosphate phosphatase (TPP)-like domains, neither activity has been detected in enzymatic assays nor has the protein been able to complement yeast TPS or TPP mutants.
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    Genomic context

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    See TPS8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (26470795..26474833, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene transcription factor Neighboring gene NHL domain-containing protein Neighboring gene K+ uptake permease 6 Neighboring gene spermidine synthase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. Avonce N, et al. Plant Physiol, 2004 Nov. PMID 15516499, Free PMC Article
    2. Trehalose metabolism in Arabidopsis: occurrence of trehalose and molecular cloning and characterization of trehalose-6-phosphate synthase homologues. Vogel G, et al. J Exp Bot, 2001 Sep. PMID 11520870
    3. Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Ramon M, et al. Plant Cell Environ, 2009 Aug. PMID 19344332
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of AtTPS1 in Arabidopsis using the 35S promoter led to a small increase in trehalose and trehalose-6-P levels.
      Title: The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334443.1
    NM_105697.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables trehalose-phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables trehalose-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    trehalose-6-phosphatase synthase S8
    NP_177186.2
    • trehalose-6-phosphatase synthase S8 (TPS8); FUNCTIONS IN: transferase activity, transferring glycosyl groups; INVOLVED IN: trehalose biosynthetic process, metabolic process; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HAD-superfamily hydrolase, subfamily IIB (InterPro:IPR006379), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: trehalose-phosphatase/synthase 9 (TAIR:AT1G23870.1); Has 4767 Blast hits to 4700 proteins in 1027 species: Archae - 58; Bacteria - 2753; Metazoa - 215; Fungi - 657; Plants - 620; Viruses - 0; Other Eukaryotes - 464 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26470795..26474833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105697.4 → NP_177186.2  trehalose-6-phosphatase synthase S8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177186.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64608, Q0WUI9
      UniProtKB/TrEMBL
      A0A068FL15, A0A5S9WR39
      Conserved Domains (3) summary
      cd03788
      Location:60 → 540
      GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
      PLN02205
      Location:1 → 834
      PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]
      pfam02358
      Location:590 → 823
      Trehalose_PPase; Trehalose-phosphatase

    2. NM_001334443.1 → NP_001321199.1  trehalose-6-phosphatase synthase S8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ69, A0A5S9WR39
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WUI9.1

    Gene LinkOut

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