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    ATG12A Ubiquitin-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841861, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATG12A
    Official Full Name
    Ubiquitin-like superfamily protein
    Primary source
    TAIR:AT1G54210
    Locus tag
    AT1G54210
    See related
    Araport:AT1G54210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APG12; ATATG12; AUTOPHAGY 12; AUTOPHAGY 12 A; F20D21.38; F20D21_38
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    Genomic context

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    See ATG12A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (20241226..20242641)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene BREVIS RADIX-like 3 Neighboring gene DNA mismatch repair Msh6-like protein Neighboring gene proline-rich family protein Neighboring gene Ribosomal protein L18ae family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. Fujioka Y, et al. J Biol Chem, 2008 Jan 25. PMID 18039664
    2. The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana. Phillips AR, et al. Genetics, 2008 Mar. PMID 18245858, Free PMC Article
    3. ATG8 lipidation and ATG8-mediated autophagy in Arabidopsis require ATG12 expressed from the differentially controlled ATG12A AND ATG12B loci. Chung T, et al. Plant J, 2010 May. PMID 20136727
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ATG12b locus is more important during basal autophagy while the ATG12a locus is more important during induced autophagy.
      Title: ATG8 lipidation and ATG8-mediated autophagy in Arabidopsis require ATG12 expressed from the differentially controlled ATG12A AND ATG12B loci.
    2. These results indicate that ATG10 is essential for ATG12 conjugation and that the ATG12-ATG5 conjugate is necessary to form autophagic vesicles and for the timely progression of senescence and programmed cell death in plants.
      Title: The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana.
    3. In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy
      Title: In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001198290.1
    NM_001333633.1
    NM_104299.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like superfamily protein
    NP_001185219.1
    • AUTOPHAGY 12 A (ATG12A); INVOLVED IN: autophagy, protein ubiquitination involved in ubiquitin-dependent protein catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Autophagy-related protein 12 (InterPro:IPR007242); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT3G13970.1).
    NP_175823.1
    • AUTOPHAGY 12 A (ATG12A); INVOLVED IN: autophagy, protein ubiquitination involved in ubiquitin-dependent protein catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Autophagy-related protein 12 (InterPro:IPR007242); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT3G13970.1); Has 304 Blast hits to 304 proteins in 150 species: Archae - 0; Bacteria - 0; Metazoa - 108; Fungi - 124; Plants - 58; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20241226..20242641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198290.1 → NP_001185219.1  Ubiquitin-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q67YB5
      Conserved Domains (1) summary
      cl00155
      Location:13 → 52
      UBQ; Ubiquitin-like proteins

    2. NM_104299.3 → NP_175823.1  Ubiquitin-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S924
      UniProtKB/TrEMBL
      A0A178VZU7, A0A5S9WLQ9
      Conserved Domains (1) summary
      cd01612
      Location:13 → 95
      Ubl_ATG12; ubiquitin-like (Ubl) domain found in autophagy-related protein 12 (ATG12)

    3. NM_001333633.1 → NP_001320241.1  Ubiquitin-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S924
      UniProtKB/TrEMBL
      A0A178VZU7, A0A5S9WLQ9
      Conserved Domains (1) summary
      cd01612
      Location:13 → 95
      Ubl_ATG12; ubiquitin-like (Ubl) domain found in autophagy-related protein 12 (ATG12)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S924.1

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