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    LINC2 nuclear matrix constituent protein-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837882, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LINC2
    Official Full Name
    nuclear matrix constituent protein-like protein
    Primary source
    TAIR:AT1G13220
    Locus tag
    AT1G13220
    See related
    Araport:AT1G13220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CROWDED NUCLEI 2; CRWN2; F3F19.25; F3F19_25; LITTLE NUCLEI2
    Summary
    Encodes a nuclear coiled-coil protein related to the carrot peripheral nuclear protein NMCP1 that is involved in the determination of plant nuclear structure.
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    Genomic context

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    See LINC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (4515464..4520306)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene autoinhibited Ca2+/ATPase II Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LITTLE NUCLEI genes affecting nuclear morphology in Arabidopsis thaliana. Dittmer TA, et al. Plant Cell, 2007 Sep. PMID 17873096, Free PMC Article
    2. Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling. Choi J, et al. Plant Physiol, 2019 Apr. PMID 30696746, Free PMC Article
    3. Arabidopsis lamin-like proteins CRWN1 and CRWN2 interact with SUPPRESSOR OF NPR1-1 INDUCIBLE 1 and RAD51D to prevent DNA damage. Yin C, et al. Plant Cell, 2023 Sep 1. PMID 37335899, Free PMC Article
    4. Roles of CRWN-family proteins in protecting genomic DNA against oxidative damage. Wang Q, et al. J Plant Physiol, 2019 Feb. PMID 30576929
    5. The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein. Zhao W, et al. J Integr Plant Biol, 2016 Jul. PMID 26564029

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutations trigger widespread changes in transcript levels and whole-plant phenotypes
      Title: Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling.
    2. role in diminishing ROS accumulation and protecting genomic DNA against excessive oxidative damage caused by methyl methanesulfonate
      Title: Roles of CRWN-family proteins in protecting genomic DNA against oxidative damage.
    3. These results suggested important roles of CRWNs in ABI5 nuclear body organization and ABI5 protein degradation during seed germination.
      Title: The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein.
    4. These results indicate that the LINC coiled-coil proteins are important determinants of plant nuclear structure. [LINC2]
      Title: LITTLE NUCLEI genes affecting nuclear morphology in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_101193.3
    NM_101194.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleus organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleus size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear matrix constituent protein-like protein
    NP_563923.1
    • LITTLE NUCLEI2 (LINC2); INVOLVED IN: nucleus organization; LOCATED IN: nucleoplasm; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: little nuclei3 (TAIR:AT1G68790.1); Has 107806 Blast hits to 52972 proteins in 2654 species: Archae - 1404; Bacteria - 16181; Metazoa - 50751; Fungi - 7829; Plants - 5203; Viruses - 291; Other Eukaryotes - 26147 (source: NCBI BLink).
    NP_563924.1
    • LITTLE NUCLEI2 (LINC2); INVOLVED IN: nucleus organization; LOCATED IN: nucleoplasm; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: little nuclei3 (TAIR:AT1G68790.1); Has 343402 Blast hits to 148924 proteins in 3995 species: Archae - 3820; Bacteria - 73706; Metazoa - 134029; Fungi - 26703; Plants - 17784; Viruses - 1471; Other Eukaryotes - 85889 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4515464..4520306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332064.1 → NP_001322783.1  nuclear matrix constituent protein-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUZ9, A0A654EEG2

    2. NM_101193.3 → NP_563923.1  nuclear matrix constituent protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SAF6
      Conserved Domains (1) summary
      TIGR02169
      Location:92 → 374
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. NM_101194.2 → NP_563924.1  nuclear matrix constituent protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563924.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HP35, Q0WQM6, Q94AW6, Q9SAF6
      UniProtKB/TrEMBL
      A0A178W3J7
      Conserved Domains (1) summary
      PTZ00121
      Location:62 → 745
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAF6.1

    Gene LinkOut

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