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    TOM2A tobamovirus multiplication 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840133, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOM2A
    Official Full Name
    tobamovirus multiplication 2A
    Primary source
    TAIR:AT1G32400
    Locus tag
    AT1G32400
    See related
    Araport:AT1G32400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5D14.17; F5D14_17; tobamovirus multiplication 2A
    Summary
    TOM2A encodes a 280 amino acid putative four-pass transmembrane protein with a C-terminal farnesylation signal, essential for efficient multiplication of tobacco mosaic viruses.
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    Genomic context

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    See TOM2A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (11689064..11691588, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Vacuolar protein sorting 55 (VPS55) family protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of host and viral proteins associated with tobamovirus RNA replication. Hagiwara Y, et al. EMBO J, 2003 Jan 15. PMID 12514140, Free PMC Article
    2. Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1. Tsujimoto Y, et al. EMBO J, 2003 Jan 15. PMID 12514139, Free PMC Article
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036050.2
    NM_102974.5
    NM_202223.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    tobamovirus multiplication 2A
    NP_001031127.1
    • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_564399.1
    • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 929 Blast hits to 927 proteins in 94 species: Archae - 0; Bacteria - 0; Metazoa - 729; Fungi - 0; Plants - 163; Viruses - 0; Other Eukaryotes - 37 (source: NCBI BLink).
    NP_973952.1
    • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11689064..11691588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102974.5 → NP_564399.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564399.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Z79, Q9C5W7, Q9LQL8
      UniProtKB/TrEMBL
      A0A5S9WMX2
      Conserved Domains (1) summary
      pfam00335
      Location:19 → 163
      Tetraspannin; Tetraspanin family

    2. NM_001036050.2 → NP_001031127.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Z79, Q9C5W7, Q9LQL8
      UniProtKB/TrEMBL
      A0A5S9WMX2
      Conserved Domains (1) summary
      pfam00335
      Location:19 → 163
      Tetraspannin; Tetraspanin family

    3. NM_202223.3 → NP_973952.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973952.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Z79, Q9C5W7, Q9LQL8
      UniProtKB/TrEMBL
      A0A5S9WMX2
      Conserved Domains (1) summary
      pfam00335
      Location:19 → 163
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5W7.1

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