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    WAK2 wall-associated kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838723, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WAK2
    Official Full Name
    wall-associated kinase 2
    Primary source
    TAIR:AT1G21270
    Locus tag
    AT1G21270
    See related
    Araport:AT1G21270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16F4.5; F16F4_5; wall-associated kinase 2
    Summary
    cytoplasmic serine/threonine protein kinase induced by salicylic acid. mutant plants exhibit a loss of cell expansion and dependence on sugars and salts for seedling growth, affecting the expression and activity of vacuolar invertase.
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    Genomic context

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    See WAK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (7444749..7448483)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cell wall-associated kinase Neighboring gene pseudo Neighboring gene Copia-like polyprotein/retrotransposon Neighboring gene miscRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pectin activation of MAP kinase and gene expression is WAK2 dependent. Kohorn BD, et al. Plant J, 2009 Dec. PMID 19737363, Free PMC Article
    2. Effects of Arabidopsis wall associated kinase mutations on ESMERALDA1 and elicitor induced ROS. Kohorn BD, et al. PLoS One, 2021. PMID 34015001, Free PMC Article
    3. An Arabidopsis cell wall-associated kinase required for invertase activity and cell growth. Kohorn BD, et al. Plant J, 2006 Apr. PMID 16623892
    4. A dominant allele of Arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations. Kohorn BD, et al. Mol Plant, 2012 Jul. PMID 22155845, Free PMC Article
    5. A cluster of five cell wall-associated receptor kinase genes, Wak1-5, are expressed in specific organs of Arabidopsis. He ZH, et al. Plant Mol Biol, 1999 Apr. PMID 10380805

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of Arabidopsis wall associated kinase mutations on ESMERALDA1 and elicitor induced ROS.
      Title: Effects of Arabidopsis wall associated kinase mutations on ESMERALDA1 and elicitor induced ROS.
    2. A mpk6, but not a mpk3, null allele is able to suppress the effects of this dominant WAK2 mutation
      Title: A dominant allele of Arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations.
    3. WAK2 plays a major role in signaling a diverse array of cellular events in response to pectin in the extracellular matrix.
      Title: Pectin activation of MAP kinase and gene expression is WAK2 dependent.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101979.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular water homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oligosaccharide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wall-associated kinase 2
    NP_173549.1
    • wall-associated kinase 2 (WAK2); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, calcium ion binding, ATP binding; INVOLVED IN: cellular water homeostasis, protein amino acid phosphorylation, oligosaccharide metabolic process, unidimensional cell growth, response to salicylic acid stimulus; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: EGF-like calcium-binding (InterPro:IPR001881), EGF-like, type 3 (InterPro:IPR000742), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), EGF-like region, conserved site (InterPro:IPR013032), Protein kinase, catalytic domain (InterPro:IPR000719), EGF-like calcium-binding, conserved site (InterPro:IPR018097), EGF-type aspartate/asparagine hydroxylation site (InterPro:IPR000152), EGF calcium-binding (InterPro:IPR013091), EGF-like (InterPro:IPR006210); BEST Arabidopsis thaliana protein match is: wall associated kinase 5 (TAIR:AT1G21230.1); Has 140654 Blast hits to 123720 proteins in 4781 species: Archae - 129; Bacteria - 13911; Metazoa - 65181; Fungi - 9585; Plants - 33448; Viruses - 437; Other Eukaryotes - 17963 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7444749..7448483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101979.4 → NP_173549.1  wall-associated kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LMP1, Q9XGN2
      UniProtKB/TrEMBL
      A0A178W4A5
      Conserved Domains (3) summary
      cd14066
      Location:410 → 677
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam07645
      Location:278 → 311
      EGF_CA; Calcium-binding EGF domain
      pfam13947
      Location:29 → 127
      GUB_WAK_bind; Wall-associated receptor kinase galacturonan-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LMP1.1

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