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    DFC DHFS-FPGS homolog C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820179, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DFC
    Official Full Name
    DHFS-FPGS homolog C
    Primary source
    TAIR:AT3G10160
    Locus tag
    AT3G10160
    See related
    Araport:AT3G10160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA DHFS-FPGS HOMOLOG C; ATDFC; DHFS-FPGS homolog C; folylpolyglutamate synthetase 2; FPGS2
    Summary
    Encodes a protein with tetrahydrofolylpolyglutamate synthase activity that is located in the mitochondrial matrix. One of the three folylpolyglutamate synthetase isoforms (FPGSs): FPGS1 (At5g05980, plastidic), FPGS2 (At3g10160, mitochondrial) and FPGS3 (At3g55630, cytosolic).
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    Genomic context

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    See DFC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (3139383..3144615, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RECA homolog 3 Neighboring gene ncRNA Neighboring gene purple acid phosphatase 16 Neighboring gene ncRNA Neighboring gene Gibberellin-regulated family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Calcium-binding EF-hand family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial folylpolyglutamate synthetase gene is required for nitrogen utilization during early seedling development in arabidopsis. Jiang L, et al. Plant Physiol, 2013 Feb. PMID 23129207, Free PMC Article
    2. Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development. Mehrshahi P, et al. Plant J, 2010 Oct. PMID 21070407
    3. Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Ravanel S, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752472, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the folylpolyglutamate synthetase mutant seedlings displayed increased levels of starch and anthocyanin synthesis as well as decreased levels of soluble protein and free amino acid.
      Title: The mitochondrial folylpolyglutamate synthetase gene is required for nitrogen utilization during early seedling development in arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_111851.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables tetrahydrofolylpolyglutamate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within photorespiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seedling development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DHFS-FPGS homolog C
    NP_187627.3
    • DHFS-FPGS homolog C (DFC); CONTAINS InterPro DOMAIN/s: Mur ligase, central (InterPro:IPR013221), Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog B (TAIR:AT5G05980.2); Has 7721 Blast hits to 7719 proteins in 2542 species: Archae - 43; Bacteria - 4847; Metazoa - 165; Fungi - 368; Plants - 133; Viruses - 0; Other Eukaryotes - 2165 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3139383..3144615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111851.6 → NP_187627.3  DHFS-FPGS homolog C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187627.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVP0, F4J2K2, Q8W038, Q9SR80
      UniProtKB/TrEMBL
      A0A5S9XBW1
      Conserved Domains (1) summary
      PLN02881
      Location:68 → 625
      PLN02881; tetrahydrofolylpolyglutamate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4J2K2.1

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