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    PPC3 phosphoenolpyruvate carboxylase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820723, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPC3
    Official Full Name
    phosphoenolpyruvate carboxylase 3
    Primary source
    TAIR:AT3G14940
    Locus tag
    AT3G14940
    See related
    Araport:AT3G14940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPPC3; phosphoenolpyruvate carboxylase 3
    Summary
    Encodes a cytosolic phosphoenolpyruvate carboxylase (PEPC) that has activity when expressed in E.coli. Its mRNA is most abundantly expressed in roots and siliques. PPC3 belongs to the plant-type PEPC family. It can form an enzymatically active complex with a castor bean ortholog of PPC4, which encodes a bacterial-type PEPC.
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    Genomic context

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    See PPC3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (5025184..5029886)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Rab3 GTPase-activating protein non-catalytic subunit Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene tetratricopetide-repeat thioredoxin-like 2 Neighboring gene Galactosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana. Connell MB, et al. J Struct Biol, 2018 Dec. PMID 30419358
    2. Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions. Feria AB, et al. Planta, 2016 Oct. PMID 27306451
    3. Bacterial- and plant-type phosphoenolpyruvate carboxylase polypeptides interact in the hetero-oligomeric Class-2 PEPC complex of developing castor oil seeds. Gennidakis S, et al. Plant J, 2007 Dec. PMID 17894783
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Citrate functions as a mixed (allosteric) inhibitor as it reduced phosphoenolpyruvate carboxylase 3 (AtPPC3)'s Vmax while increasing Km(PEP) values.
      Title: Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana.
    2. Phosphoenolpyruvate carboxylase (PEPC) activity was decreased in shoots and roots of ppc2 and ppc3 mutants, and phosphate starvation increased the expression of all PEPC and phosphoenolpyruvate carboxylase kinase genes in shoots, but only PPC3 and PPCK2 in roots
      Title: Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338141.1
    NM_112356.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoenolpyruvate carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxylase 3
    NP_188112.1
    • phosphoenolpyruvate carboxylase 3 (PPC3); FUNCTIONS IN: phosphoenolpyruvate carboxylase activity; INVOLVED IN: response to salt stress, tricarboxylic acid cycle; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 1 (TAIR:AT1G53310.3); Has 6864 Blast hits to 6805 proteins in 1910 species: Archae - 27; Bacteria - 2657; Metazoa - 5; Fungi - 0; Plants - 1758; Viruses - 0; Other Eukaryotes - 2417 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5025184..5029886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112356.4 → NP_188112.1  phosphoenolpyruvate carboxylase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81357, Q0WTJ7, Q84VW9
      UniProtKB/TrEMBL
      A0A178VET0, A0A5S9XC87
      Conserved Domains (2) summary
      COG2352
      Location:25 → 968
      Ppc; Phosphoenolpyruvate carboxylase [Energy production and conversion]
      pfam00311
      Location:164 → 968
      PEPcase; Phosphoenolpyruvate carboxylase

    2. NM_001338141.1 → NP_001326778.1  phosphoenolpyruvate carboxylase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81357, Q0WTJ7, Q84VW9
      UniProtKB/TrEMBL
      A0A178VET0, A0A5S9XC87
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84VW9.2

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