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    E12A11 PEBP (phosphatidylethanolamine-binding protein) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838390, updated on 18-Sep-2024

    Summary

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    Official Symbol
    E12A11
    Official Full Name
    PEBP (phosphatidylethanolamine-binding protein) family protein
    Primary source
    TAIR:AT1G18100
    Locus tag
    AT1G18100
    See related
    Araport:AT1G18100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MFT; MOTHER OF FT AND TFL1; T10F20.11
    Summary
    Encodes a member of the FT and TFL1 family of phosphatidylethanolamine-binding proteins. It is expressed in seeds and up-regulated in response to ABA. Loss of function mutants show decreased rate of germination in the presence of ABA. ABA dependent regulation is mediated by both ABI3 and ABI5. ABI5 promotes MFT expression, primarily in the radicle-hypocotyl transition zone and ABI3 suppresses it in the seed.
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    Genomic context

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    See E12A11 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (6227217..6230194, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene 5'-3' exonuclease family protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene Class II aaRS and biotin synthetases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MOTHER OF FT AND TFL1 regulates seed germination and fertility relevant to the brassinosteroid signaling pathway. Xi W, et al. Plant Signal Behav, 2010 Oct. PMID 20935478, Free PMC Article
    2. MOTHER OF FT AND TFL1 regulates seed germination through a negative feedback loop modulating ABA signaling in Arabidopsis. Xi W, et al. Plant Cell, 2010 Jun. PMID 20551347, Free PMC Article
    3. Temperature, light and nitrate sensing coordinate Arabidopsis seed dormancy cycling, resulting in winter and summer annual phenotypes. Footitt S, et al. Plant J, 2013 Jun. PMID 23590427, Free PMC Article
    4. A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA. Footitt S, et al. Plant Cell Environ, 2017 Aug. PMID 28240777, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. using mutants in known dormancy-related genes [DELAY OF GERMINATION 1 (DOG1), MOTHER OF FLOWERING TIME (MFT), CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) and PHYTOCHROME A (PHYA)] components of the circadian clock are shown to be involved in coordination of the annual seed dormancy cycle.
      Title: A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA.
    2. Unlike DOG1, expression of MOTHER of FLOWERING TIME (MFT) has an opposite thermal response in seeds of the two ecotypes, and may therefore have a role in their different dormancy cycling phenotypes.
      Title: Temperature, light and nitrate sensing coordinate Arabidopsis seed dormancy cycling, resulting in winter and summer annual phenotypes.
    3. MFT function is also relevant to the brassinosteroids signaling pathway.
      Title: MOTHER OF FT AND TFL1 regulates seed germination and fertility relevant to the brassinosteroid signaling pathway.
    4. During seed germination, MFT promotes embryo growth by constituting a negative feedback loop in the ABA signaling pathway.
      Title: MOTHER OF FT AND TFL1 regulates seed germination through a negative feedback loop modulating ABA signaling in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_101672.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PEBP (phosphatidylethanolamine-binding protein) family protein
    NP_173250.1
    • E12A11; CONTAINS InterPro DOMAIN/s: Phosphatidylethanolamine-binding, conserved site (InterPro:IPR001858), Phosphatidylethanolamine-binding protein PEBP (InterPro:IPR008914); BEST Arabidopsis thaliana protein match is: PEBP (phosphatidylethanolamine-binding protein) family protein (TAIR:AT5G03840.1); Has 2417 Blast hits to 2417 proteins in 371 species: Archae - 0; Bacteria - 118; Metazoa - 639; Fungi - 192; Plants - 1429; Viruses - 3; Other Eukaryotes - 36 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6227217..6230194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101672.4 → NP_173250.1  PEBP (phosphatidylethanolamine-binding protein) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XFK7
      UniProtKB/TrEMBL
      A0A178W7F0, A0A5S9V079
      Conserved Domains (1) summary
      cl00227
      Location:6 → 173
      PEBP; PhosphatidylEthanolamine-Binding Protein (PEBP) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XFK7.1

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