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    HAC12 histone acetyltransferase of the CBP family 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838242, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAC12
    Official Full Name
    histone acetyltransferase of the CBP family 12
    Primary source
    TAIR:AT1G16710
    Locus tag
    AT1G16710
    See related
    Araport:AT1G16710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19K19.17; histone acetyltransferase of the CBP family 12
    Summary
    Encodes an enzyme with histone acetyltransferase activity that can use both H3 and H4 histones as substrates. No single prior lysine acetylation is sufficient to block HAC12 acetylation of the H3 or H4 peptides, suggesting that HAC12 can acetylate any of several lysines present in the peptides.
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    Genomic context

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    See HAC12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (5713794..5722614)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Enhancer of polycomb-like transcription factor protein Neighboring gene Alpha-helical ferredoxin Neighboring gene p300/CBP acetyltransferase-related protein-like protein Neighboring gene ncRNA Neighboring gene high chlorophyll fluorescence phenotype 173 Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of plant CBP/p300-like genes in the regulation of flowering time. Han SK, et al. Plant J, 2007 Jan. PMID 17144897
    2. In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Earley KW, et al. Plant J, 2007 Nov. PMID 17877703
    3. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_101532.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the CBP family 12
    NP_001185015.1
    • histone acetyltransferase of the CBP family 12 (HAC12); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: flower development, regulation of transcription, DNA-dependent, protein amino acid acetylation; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 1 (TAIR:AT1G79000.1).
    NP_173115.1
    • histone acetyltransferase of the CBP family 12 (HAC12); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: flower development, regulation of transcription, DNA-dependent, protein amino acid acetylation; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 1 (TAIR:AT1G79000.1); Has 5603 Blast hits to 4159 proteins in 302 species: Archae - 0; Bacteria - 235; Metazoa - 1739; Fungi - 482; Plants - 447; Viruses - 18; Other Eukaryotes - 2682 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5713794..5722614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332246.1 → NP_001321737.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

    2. NM_001332247.1 → NP_001321739.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

    3. NM_001332248.1 → NP_001321738.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

    4. NM_001332249.1 → NP_001321742.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

    5. NM_001332250.1 → NP_001321741.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

    6. NM_001332251.1 → NP_001321736.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

    7. NM_001332252.1 → NP_001321735.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARU4, A0A5S9UR80, A0A654EAH3

    8. NM_001332245.1 → NP_001321740.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

    9. NM_001198086.1 → NP_001185015.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9UR80, A0A654EAH3, F4I4I8
      Conserved Domains (4) summary
      smart00551
      Location:609 → 687
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd15614
      Location:971 → 1043
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl00295
      Location:1502 → 1547
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl02120
      Location:1117 → 1315
      HAT_KAT11; Histone acetylation protein

    10. NM_101532.3 → NP_173115.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FWQ5
      UniProtKB/TrEMBL
      A0A5S9UR80, A0A654EAH3
      Conserved Domains (4) summary
      smart00551
      Location:638 → 716
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd15614
      Location:1000 → 1072
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl00295
      Location:1531 → 1576
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl02120
      Location:1146 → 1344
      HAT_KAT11; Histone acetylation protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FWQ5.2

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