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    Hop3 stress-inducible protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826849, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hop3
    Official Full Name
    stress-inducible protein
    Primary source
    TAIR:AT4G12400
    Locus tag
    AT4G12400
    See related
    Araport:AT4G12400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T1P17.2
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    See Hop3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (7338018..7341363, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene F-box/kelch-repeat protein Neighboring gene uncharacterized protein Neighboring gene F-box family protein Neighboring gene pectin methylesterase inhibitor 1 Neighboring gene tRNA-Asn Neighboring gene SAUR-like auxin-responsive protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HOP3 a new regulator of the ER stress response in Arabidopsis with possible implications in plant development and response to biotic and abiotic stresses. Fernández-Bautista N, et al. Plant Signal Behav, 2017 May 4. PMID 28426278, Free PMC Article
    2. The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity. Muñoz A, et al. Plant Physiol, 2021 Nov 3. PMID 34618051, Free PMC Article
    3. HOP3, a member of the HOP family in Arabidopsis, interacts with BiP and plays a major role in the ER stress response. Fernández-Bautista N, et al. Plant Cell Environ, 2017 Aug. PMID 28155228
    4. A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis. Charng YY, et al. Plant Physiol, 2007 Jan. PMID 17085506, Free PMC Article
    5. Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by interacting with each other via the PPC/DUF296 domain. Zhao J, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218605, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity.
      Title: The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity.
    2. Arabidopsis HOP3, whose function was not studied before, interacts in vivo with cytosolic HSP90 and HSP70, and, unexpectedly, with binding immunoglobulin protein (BiP), a HSP70 endoplasmic reticulum-resident protein.
      Title: HOP3, a member of the HOP family in Arabidopsis, interacts with BiP and plays a major role in the ER stress response.
    3. findings open the exciting possibility that HOP3, through its role in the alleviation of ER stress, could play an important function during different developmental processes and in response to different biotic and abiotic stresses.
      Title: HOP3 a new regulator of the ER stress response in Arabidopsis with possible implications in plant development and response to biotic and abiotic stresses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036543.2
    NM_117310.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Hsp90 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables preprotein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    stress-inducible protein
    NP_001031620.1
    • stress-inducible protein, putative; FUNCTIONS IN: binding; INVOLVED IN: response to high light intensity, response to hydrogen peroxide, response to heat, response to stress; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: stress-inducible protein, putative (TAIR:AT1G62740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_192977.2
    • stress-inducible protein, putative; FUNCTIONS IN: binding; INVOLVED IN: response to high light intensity, response to hydrogen peroxide, response to heat, response to stress; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: stress-inducible protein, putative (TAIR:AT1G62740.1); Has 51058 Blast hits to 20866 proteins in 1460 species: Archae - 1964; Bacteria - 17234; Metazoa - 10505; Fungi - 2946; Plants - 4231; Viruses - 7; Other Eukaryotes - 14171 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7338018..7341363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036543.2 → NP_001031620.1  stress-inducible protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DG66, F4JQM6, Q8L724, Q9STH1
      UniProtKB/TrEMBL
      A0A7G2EXL1
      Conserved Domains (5) summary
      smart00727
      Location:507 → 546
      STI1; Heat shock chaperonin-binding motif
      sd00006
      Location:369 → 397
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:70 → 103
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:369 → 434
      TPR_11; TPR repeat
      pfam13424
      Location:264 → 337
      TPR_12; Tetratricopeptide repeat

    2. NM_117310.4 → NP_192977.2  stress-inducible protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192977.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EXL1
      Conserved Domains (4) summary
      sd00006
      Location:369 → 397
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:70 → 103
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:369 → 434
      TPR_11; TPR repeat
      pfam13424
      Location:264 → 337
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STH1.1

    Gene LinkOut

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