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    ChaC-like family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829256, updated on 18-Sep-2024

    Summary

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    Official Full Name
    ChaC-like family protein
    Primary source
    TAIR:AT4G31290
    Locus tag
    AT4G31290
    See related
    Araport:AT4G31290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGGCT2;2; F8F16.110; F8F16_110; gamma-glutamyl cyclotransferase 2;2; GGCT2;2
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (15185775..15188484)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene sequence-specific DNA binding transcription factor Neighboring gene uncharacterized protein Neighboring gene N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein Neighboring gene AIG2-like (avirulence induced gene) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation. Joshi NC, et al. New Phytol, 2019 Feb. PMID 30368820
    2. A γ-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis. Paulose B, et al. Plant Cell, 2013 Nov. PMID 24214398, Free PMC Article
    3. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, et al. Biochem J, 2015 May 15. PMID 25716890
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_119278.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ChaC-like family protein
    NP_567871.1
    • ChaC-like family protein; CONTAINS InterPro DOMAIN/s: ChaC-like protein (InterPro:IPR006840); BEST Arabidopsis thaliana protein match is: ChaC-like family protein (TAIR:AT5G26220.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15185775..15188484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119278.6 → NP_567871.1  ChaC-like family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49579, Q84MC1, Q8LAB4
      UniProtKB/TrEMBL
      A0A178UTF7, A0A5S9XXJ6, A0A7G2F2E3
      Conserved Domains (1) summary
      cl22886
      Location:3 → 180
      GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MC1.1

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