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    CYP82C4 cytochrome P450, family 82, subfamily C, polypeptide 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829324, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP82C4
    Official Full Name
    cytochrome P450, family 82, subfamily C, polypeptide 4
    Primary source
    TAIR:AT4G31940
    Locus tag
    AT4G31940
    See related
    Araport:AT4G31940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; F11C18.7; family 82; polypeptide 4; polypeptide 4''; subfamily C
    Summary
    The gene encodes a cytochrome P450 enzyme, CYP82C. It is involved in the early Fe deficiency response.
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    Genomic context

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    See CYP82C4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (15451988..15454224)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene response regulator 10 Neighboring gene Mitochondrial glycoprotein family protein Neighboring gene cytochrome P450, family 82, subfamily C, polypeptide 3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CYP82C4 expression is dependent on Fe availability and circadian rhythm, and correlates with genes involved in the early Fe deficiency response. Murgia I, et al. J Plant Physiol, 2011 Jun 15. PMID 21315474
    2. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Rajniak J, et al. Nat Chem Biol, 2018 May. PMID 29581584, Free PMC Article
    3. In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures. Kruse T, et al. Chem Biol, 2008 Feb. PMID 18291319
    4. A major role of coumarin-dependent ferric iron reduction in strategy I-type iron acquisition in Arabidopsis. Paffrath V, et al. Plant Cell, 2024 Feb 26. PMID 38016103, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP82C4 (cytochrome P450, family 82, subfamily C, polypeptide 4 ) expression correlates with expression of genes involved in metal uptake and transport.
      Title: Arabidopsis CYP82C4 expression is dependent on Fe availability and circadian rhythm, and correlates with genes involved in the early Fe deficiency response.
    Submit: New GeneRIF Correction

    General gene information

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    NM_119345.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fraxetin 5-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to alkaline pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to alkaline pH IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sideretin biosynthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450, family 82, subfamily C, polypeptide 4
    NP_194922.1
    • ''cytochrome P450, family 82, subfamily C, polypeptide 4'' (CYP82C4); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: oxidation reduction; LOCATED IN: endomembrane system; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 82, subfamily C, polypeptide 2 (TAIR:AT4G31970.1); Has 33616 Blast hits to 33393 proteins in 1726 species: Archae - 49; Bacteria - 3806; Metazoa - 11816; Fungi - 7242; Plants - 9457; Viruses - 3; Other Eukaryotes - 1243 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15451988..15454224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119345.3 → NP_194922.1  cytochrome P450, family 82, subfamily C, polypeptide 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SZ46
      UniProtKB/TrEMBL
      A0A178V6C0, A0A5S9XXT0
      Conserved Domains (1) summary
      cl12078
      Location:5 → 518
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZ46.1

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