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    VAB2 ATPase, V1 complex, subunit B protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830008, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VAB2
    Official Full Name
    ATPase, V1 complex, subunit B protein
    Primary source
    TAIR:AT4G38510
    Locus tag
    AT4G38510
    See related
    Araport:AT4G38510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtVAB2; F22I13.8; V-ATPase B subunit 2; VHA-B2
    Summary
    One of three genes encoding the vacuolar ATP synthase subunit B1. The protein binds to and co-localizes with F-actin, bundles F-actin to form higher-order structure, and stabilizes actin filaments in vitro.
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    Genomic context

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    See VAB2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Sequence:
    Chromosome: 4; NC_003075.7 (18010812..18015173, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene chromatin-remodeling complex subunit Neighboring gene Sept9 (DUF616) Neighboring gene Protein phosphatase 2C family protein Neighboring gene phospholipase C1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence. Liu J, et al. Plant Physiol, 2016 Mar. PMID 26739232, Free PMC Article
    2. Arabidopsis vacuolar H+-ATPase (V-ATPase) B subunits are involved in actin cytoskeleton remodeling via binding to, bundling, and stabilizing F-actin. Ma B, et al. J Biol Chem, 2012 Jun 1. PMID 22371505, Free PMC Article
    3. SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity. Batelli G, et al. Mol Cell Biol, 2007 Nov. PMID 17875927, Free PMC Article
    4. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    5. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036730.2
    NM_001036731.2
    NM_001204025.1
    NM_120012.4
    NM_202978.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    ATPase, V1 complex, subunit B protein
    NP_001031807.1
    • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
    NP_001031808.1
    • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
    NP_001190954.1
    • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1).
    NP_195563.1
    • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism, ATP binding; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
    NP_974707.1
    • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18010812..18015173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202978.2 → NP_974707.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974707.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
      UniProtKB/TrEMBL
      A0A178V0N0, A0A5S9XZS3, A0A7G2F713
      Conserved Domains (1) summary
      TIGR01040
      Location:19 → 484
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    2. NM_001036730.2 → NP_001031807.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
      UniProtKB/TrEMBL
      A0A178V0N0, A0A5S9XZS3, A0A7G2F713
      Conserved Domains (1) summary
      TIGR01040
      Location:19 → 484
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    3. NM_001036731.2 → NP_001031808.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
      UniProtKB/TrEMBL
      A0A178V0N0, A0A5S9XZS3, A0A7G2F713
      Conserved Domains (1) summary
      TIGR01040
      Location:19 → 484
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    4. NM_120012.4 → NP_195563.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
      UniProtKB/TrEMBL
      A0A178V0N0, A0A5S9XZS3, A0A7G2F713
      Conserved Domains (1) summary
      TIGR01040
      Location:19 → 484
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    5. NM_001204025.1 → NP_001190954.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F713, F4JTQ0
      Conserved Domains (4) summary
      cd01135
      Location:98 → 385
      V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
      TIGR01040
      Location:26 → 491
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
      pfam00306
      Location:401 → 492
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:30 → 96
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZN1.1

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