CEV1 Cellulose synthase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CEV1
Official Full Name: Cellulose synthase family protein
Primary source: TAIR:AT5G05170
Locus tag: AT5G05170
See related: Araport:AT5G05170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCESA3; ATH-B; CELLULOSE SYNTHASE 3; CESA3; CONSTITUTIVE EXPRESSION OF VSP 1; ECTOPIC LIGNIFICATION 1; ELI1; ISOXABEN RESISTANT 1; ISOXABEN RESISTANT 1; IXR1; K2A11.4; K2A11_4; MRE1; multiple response expansion 1
Summary: Encodes a cellulose synthase isomer. CESA3 mutants have cellulose defect in the primary cell wall. Multiple lines of evidence suggest that CESA3, along with CESA1 and CESA6 are present in the same plasma membrane complex for cellulose biosynthesis. As inferred from the null role of secondary wall-type CesAs, included in a set of five primary wall-type CesAs that may support trichome cell wall thickening. The xylem cells in primary root have reduced cell expansion and higher than normal lignification.
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Genomic context

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See CEV1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 15

Sequence:: Chromosome: 5; NC_003076.8 (1530132..1535558, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase.
Title: Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase.
Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories.
Title: Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories.
The results indicate that TRM4 is essential for microtubule array organization and therefore correct cellulose orientation in the SCE cells, as well as the establishment of the subsequent mucilage architecture.
Title: TRM4 is essential for cellulose deposition in Arabidopsis seed mucilage by maintaining cortical microtubule organization and interacting with CESA3.
The phenotypes observed in the trans-heterozygotes indicate that the mre1 and cev1 alleles of the AtCesA3 gene display intragenic complementation.
Title: Two alleles of the AtCesA3 gene in Arabidopsis thaliana display intragenic complementation.
The stoichiometry of the cellulose synthase catalytic subunits (CESAs) in the primary cell wall CSC was determined and CESA1, CESA3, and CESA6 are present in a 1:1:1 molecular ratio.
Title: Catalytic subunit stoichiometry within the cellulose synthase complex.
PI4K and PI3K are required for distinct steps in secretory and/or endocytic trafficking of CESA3.
Title: Phosphatidylinositol 3-kinase and 4-kinase have distinct roles in intracellular trafficking of cellulose synthase complexes in Arabidopsis thaliana.
computational findings on transmembrane helices (TMHs) 5 and 6 in three CESAs of Arabidopsis thaliana (AtCESA1, 3, and 6), the Atcesa3(ixr1-2) mutant, and a novel missense mutation in AtCESA1, are reported.
Title: Computational and genetic evidence that different structural conformations of a non-catalytic region affect the function of plant cellulose synthase.
The cell walls in the roots of these four AtCESA3 alleles contain different percentages of cellulose, and these percentages correlate with the lengths of the roots and cortex cells in these roots when grown on media containing high levels of sucrose.
Title: Four alleles of AtCESA3 form an allelic series with respect to root phenotype in Arabidopsis thaliana.
CESA1(A903V) and CESA3(T942I) have modified microfibril structure in terms of crystallinity and suggest that in plants, as in bacteria, crystallization biophysically limits polymerization.
Title: Cellulose microfibril crystallinity is reduced by mutating C-terminal transmembrane region residues CESA1A903V and CESA3T942I of cellulose synthase.
Data test that hypothesis using Arabidopsis plants expressing the cellulose synthase GFP-CESA3 and show that cellulose synthase trajectories do rotate over several hours.
Title: The rotation of cellulose synthase trajectories is microtubule dependent and influences the texture of epidermal cell walls in Arabidopsis hypocotyls.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120599.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cellulose synthase (UDP-forming) activity	IEA Inferred from Electronic Annotation more info
enables cellulose synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cellulose synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant-type primary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type primary cell wall biogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of carbohydrate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in trans-Golgi network	HDA more info	PubMed

General protein information

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Preferred Names: Cellulose synthase family protein

NP_196136.1

CONSTITUTIVE EXPRESSION OF VSP 1 (CEV1); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: primary cell wall biogenesis, cellulose biosynthetic process, defense response; LOCATED IN: Golgi apparatus, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: cellulose synthase 1 (TAIR:AT4G32410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1530132..1535558 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120599.4 → NP_196136.1 Cellulose synthase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196136.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48948, Q0WLU1, Q941L0, Q9FHK6

UniProtKB/TrEMBL

A0A178UN95, A0A384K963, A0A7G2F5X3, W8Q6G0

Conserved Domains (1) summary

PLN02638
Location:1 → 1065

PLN02638; cellulose synthase A (UDP-forming), catalytic subunit