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    AK-LYS1 aspartate kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831169, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AK-LYS1
    Official Full Name
    aspartate kinase 1
    Primary source
    TAIR:AT5G13280
    Locus tag
    AT5G13280
    See related
    Araport:AT5G13280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AK; AK1; ASPARTATE KINASE; aspartate kinase 1; ASPARTATE KINASE 1; T31B5.100; T31B5_100
    Summary
    Asp kinase inhibited by Lys and S-adenosylmethionine. Contains regulatory domains that belong to the ACT domain family, which allow binding to a extreme variety of ligands. Can function as a monomer or as a dimer with acetohydroxyacid synthase (HSDH).
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    Genomic context

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    See AK-LYS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (4249312..4253264)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myosin Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein Neighboring gene ARF GTPase-activating protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of an Arabidopsis thaliana cDNA coding for a monofunctional aspartate kinase. Frankard V, et al. Plant Mol Biol, 1997 May. PMID 9207839
    2. Allosteric monofunctional aspartate kinases from Arabidopsis. Curien G, et al. FEBS J, 2007 Jan. PMID 17140415
    3. Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents. Clark TJ, et al. Plant Physiol, 2015 Aug. PMID 26063505, Free PMC Article
    4. A novel organization of ACT domains in allosteric enzymes revealed by the crystal structure of Arabidopsis aspartate kinase. Mas-Droux C, et al. Plant Cell, 2006 Jul. PMID 16731588, Free PMC Article
    5. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that mutations in the Asp kinases (AKs) and dual-functional Asp kinase-homoserine dehydrogenases (AK-HSDHs) result in reduced transcript levels and gene product activitiee and increases in the contents of Asp-derived amino acids.
      Title: Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents.
    2. Results describe the dimeric structure of a lysine and S-adenosylmethionine-sensitive aspartate kinase isoform from Arabidopsis thaliana in complex with its two inhibitors.
      Title: A novel organization of ACT domains in allosteric enzymes revealed by the crystal structure of Arabidopsis aspartate kinase.
    3. The Arabidopsis genome contains three genes for monofunctional aspartate kinases. Aspartate kinase 2 and aspartate kinase 3 are inhibited only by lysine, and aspartate kinase 1 is inhibited in a synergistic manner by lysine and SAM. [AK1]
      Title: Allosteric monofunctional aspartate kinases from Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121331.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aspartate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    aspartate kinase 1
    NP_196832.1
    • aspartate kinase 1 (AK-LYS1); FUNCTIONS IN: aspartate kinase activity; INVOLVED IN: cellular amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate kinase, conserved site (InterPro:IPR018042), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Amino acid-binding ACT (InterPro:IPR002912), Aspartate kinase domain (InterPro:IPR001341); BEST Arabidopsis thaliana protein match is: aspartate kinase 3 (TAIR:AT3G02020.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4249312..4253264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121331.3 → NP_196832.1  aspartate kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23152, Q9LYU8
      UniProtKB/TrEMBL
      A0A178UUC2, A0A5S9Y3P9
      Conserved Domains (1) summary
      PLN02551
      Location:45 → 554
      PLN02551; aspartokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYU8.1

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