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    poly ADP-ribose polymerase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832308, updated on 18-Sep-2024

    Summary

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    Official Full Name
    poly ADP-ribose polymerase 3
    Primary source
    TAIR:AT5G22470
    Locus tag
    AT5G22470
    See related
    Araport:AT5G22470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPARP3; MQJ16.1; MQJ16_1; PARP3; Poly(ADP-Ribose) Polymerase 3
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (7446962..7451049)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L1p/L10e family Neighboring gene spectrin beta chain, brain Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ZPR1 zinc-finger domain protein Neighboring gene O-acyltransferase (WSD1-like) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage. Gu Z, et al. BMC Plant Biol, 2019 Aug 19. PMID 31426748, Free PMC Article
    2. Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis. Pham PA, et al. Plant Mol Biol, 2015 Nov. PMID 26428915, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtPARP3 has lost poly (ADP-ribose) polymerase activity in plants and performs different functions from those of AtPARP1 and AtPARP2. AtPARP1, instead of AtPARP2, plays the predominant role in PAR synthesis in both seeds and seedlings.
      Title: New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage.
    2. PARP isoforms play non-redundant non-nuclear metabolic roles and that their function is highly important in rapidly growing tissues such as the shoot apical meristem, roots and seeds. [PARP3]
      Title: Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001343735.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    poly ADP-ribose polymerase 3
    NP_001318618.1
    • NAD+ ADP-ribosyltransferases;NAD+ ADP-ribosyltransferases; FUNCTIONS IN: NAD+ ADP-ribosyltransferase activity; INVOLVED IN: protein amino acid ADP-ribosylation; LOCATED IN: intracellular, nucleus; CONTAINS InterPro DOMAIN/s: WGR (InterPro:IPR008893), Poly(ADP-ribose) polymerase, regulatory domain (InterPro:IPR004102), PADR1 (InterPro:IPR012982), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: poly(ADP-ribose) polymerase 2 (TAIR:AT2G31320.1); Has 672 Blast hits to 662 proteins in 152 species: Archae - 0; Bacteria - 20; Metazoa - 347; Fungi - 74; Plants - 111; Viruses - 2; Other Eukaryotes - 118 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7446962..7451049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343735.1 → NP_001318618.1  poly ADP-ribose polymerase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K9W5, Q8GXP3, Q9FK91
      UniProtKB/TrEMBL
      A0A2H1ZE65
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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