ATR Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATR
Official Full Name: Ataxia telangiectasia-mutated and RAD3-like protein
Primary source: TAIR:AT5G40820
Locus tag: AT5G40820
See related: Araport:AT5G40820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED; ATATR; Ataxia telangiectasia-mutated and RAD3-related; ATRAD3; MHK7.5; MHK7_5
Summary: Encodes a Arabidopsis ortholog of the ATR protein kinase that is involved in a wide range of responses to DNA damage and plays a central role in cell-cycle regulation. Dominant loss of function alleles identified as suppressors of ALS also exhibit increased tolerance to aluminum. This may be due to the inhibition of terminal differentiation of the root apex upon exposure to Al.
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Genomic context

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See ATR in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 16

Sequence:: Chromosome: 5; NC_003076.8 (16342728..16353898, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
Title: ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
Protein kinase ATR inhibits E3 ubiquitin ligase CRL4[PRL1] to stabilize ribonucleotide reductase in response to replication stress.
Title: Protein kinase ATR inhibits E3 ubiquitin ligase CRL4(PRL1) to stabilize ribonucleotide reductase in response to replication stress.
The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
Title: The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
Title: The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
Mutant ATR and ATM seeds are highly resistant to aging, establishing ATM and ATR as determinants of seed viability.
Title: DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.
ATR function together with SOG1 and ALT2 to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.
Title: Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.
Title: A stable RNA G-quadruplex within the 5'-UTR of Arabidopsis thaliana ATR mRNA inhibits translation.
ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.
Title: ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis.
findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
Title: ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.
TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.
Title: The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition.

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General gene information

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NM_001344355.1

Supported by ESTs:

NM_001344356.1

Supported by ESTs:

NM_001344357.1

Supported by ESTs:

NM_123447.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organismal reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chromosome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to aluminum ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere maintenance in response to DNA damage	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Ataxia telangiectasia-mutated and RAD3-like protein

NP_198898.2

Ataxia telangiectasia-mutated and RAD3-related (ATR); FUNCTIONS IN: protein serine/threonine kinase activity, inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: in 9 processes; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), UME (InterPro:IPR012993), Protein kinase-like domain (InterPro:IPR011009), PIK-related kinase, FAT (InterPro:IPR003151), Armadillo-type fold (InterPro:IPR016024), PIK-related kinase (InterPro:IPR014009), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), PIK-related kinase, FATC (InterPro:IPR003152); BEST Arabidopsis thaliana protein match is: ataxia-telangiectasia mutated (TAIR:AT3G48190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16342728..16353898 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123447.3 → NP_198898.2 Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198898.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FKS4, Q9MAZ4

UniProtKB/TrEMBL

A0A654G6W9

Conserved Domains (3) summary

smart00802
Location:1088 → 1194

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

COG5032
Location:1692 → 2702

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd00892
Location:2363 → 2638

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
NM_001344356.1 → NP_001332643.1 Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FKS4, Q9MAZ4

UniProtKB/TrEMBL

A0A654G6W9

Conserved Domains (3) summary

smart00802
Location:1088 → 1194

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

COG5032
Location:1692 → 2702

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd00892
Location:2363 → 2638

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
NM_001344355.1 → NP_001332644.1 Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1R7T394, A0A654G6W9
NM_001344357.1 → NP_001332642.1 Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FKS4, Q9MAZ4

UniProtKB/TrEMBL

A0A654G6W9

Conserved Domains (3) summary

smart00802
Location:1088 → 1194

UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

COG5032
Location:1692 → 2702

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd00892
Location:2363 → 2638

PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins