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    Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834557, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT5G45210
    Locus tag
    AT5G45210
    See related
    Araport:AT5G45210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K18C1.9; K18C1_9
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (18295437..18298642)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Cyclin family protein Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An atypical NLR gene confers bacterial wilt susceptibility in Arabidopsis. Demirjian C, et al. Plant Commun, 2023 Sep 11. PMID 37098653, Free PMC Article
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_199334.1
    • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT3G51560.1); Has 10308 Blast hits to 9808 proteins in 326 species: Archae - 8; Bacteria - 189; Metazoa - 13; Fungi - 1; Plants - 9989; Viruses - 0; Other Eukaryotes - 108 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18295437..18298642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344599.1 → NP_001332331.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGN8

    2. NM_001344598.1 → NP_001332328.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U9C1, A0A1P8BGK7

    3. NM_001344600.1 → NP_001332330.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGN2, A0A654G864

    4. NM_001344601.1 → NP_001332329.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGN6, A0A654G864

    5. NM_123889.2 → NP_199334.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G864, Q9FKE4
      Conserved Domains (6) summary
      cd00009
      Location:196 → 304
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      sd00033
      Location:530 → 558
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:9 → 168
      TIR; TIR domain
      pfam07725
      Location:580 → 599
      LRR_3; Leucine Rich Repeat
      pfam12799
      Location:625 → 658
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:579 → 658
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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