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    FIB1 fibrillarin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835323, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FIB1
    Official Full Name
    fibrillarin 1
    Primary source
    TAIR:AT5G52470
    Locus tag
    AT5G52470
    See related
    Araport:AT5G52470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFBR1; ATFIB1; FBR1; fibrillarin 1; FIBRILLARIN 1; K24M7.22; K24M7_22; SKIP7; SKP1/ASK1-INTERACTING PROTEIN
    Summary
    encodes a fibrillarin, a key nucleolar protein in eukaryotes which associates with box C/D small nucleolar RNAs (snoRNAs) directing 2'-O-ribose methylation of the rRNA. This gene also encodes a novel box C/D snoRNA, U60.1f in its fifth intron that accumulates in seedlings and that their targeted residue on the 25 S rRNA is methylated.
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    Genomic context

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    See FIB1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (21294147..21296819)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Bacterial sec-independent translocation protein mttA/Hcf106 Neighboring gene MATE efflux family protein Neighboring gene FBD, F-box and Leucine Rich Repeat domains containing protein Neighboring gene ncRNA Neighboring gene RNI-like superfamily protein Neighboring gene Fibrillarin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and targeting of a fibrillarin homolog from Arabidopsis. Pih KT, et al. Plant Physiol, 2000 May. PMID 10806224, Free PMC Article
    2. Fibrillarin genes encode both a conserved nucleolar protein and a novel small nucleolar RNA involved in ribosomal RNA methylation in Arabidopsis thaliana. Barneche F, et al. J Biol Chem, 2000 Sep 1. PMID 10829025
    3. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. Farrás R, et al. EMBO J, 2001 Jun 1. PMID 11387208, Free PMC Article
    4. Arabidopsis ACINUS is O-glycosylated and regulates transcription and alternative splicing of regulators of reproductive transitions. Bi Y, et al. Nat Commun, 2021 Feb 11. PMID 33574257, Free PMC Article
    5. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125946.1
    NM_124626.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA methylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    fibrillarin 1
    NP_001119418.1
    • fibrillarin 1 (FIB1); FUNCTIONS IN: snoRNA binding; INVOLVED IN: RNA methylation, rRNA processing; LOCATED IN: nucleolus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 2 (TAIR:AT4G25630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_568772.3
    • fibrillarin 1 (FIB1); FUNCTIONS IN: snoRNA binding; INVOLVED IN: RNA methylation, rRNA processing; LOCATED IN: nucleolus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 2 (TAIR:AT4G25630.1); Has 20161 Blast hits to 7736 proteins in 898 species: Archae - 267; Bacteria - 4851; Metazoa - 6936; Fungi - 1342; Plants - 4220; Viruses - 452; Other Eukaryotes - 2093 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21294147..21296819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124626.5 → NP_568772.3  fibrillarin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568772.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H6E7, Q0WLG3, Q9FEF8, Q9FUZ8, Q9SP30
      UniProtKB/TrEMBL
      A0A178UA89, A0A5S9YDW7, A0A654GA95
      Conserved Domains (1) summary
      PTZ00146
      Location:64 → 304
      PTZ00146; fibrillarin; Provisional

    2. NM_001125946.1 → NP_001119418.1  fibrillarin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FEF8
      Conserved Domains (1) summary
      cl17173
      Location:64 → 226
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FEF8.1

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