ACBP1 acyl-CoA binding protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACBP1
Official Full Name: acyl-CoA binding protein 1
Primary source: TAIR:AT5G53470
Locus tag: AT5G53470
See related: Araport:AT5G53470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACBP; ACYL-COA BINDING PROTEIN; acyl-CoA binding protein 1; AtACBP1; MYN8.8; MYN8_8
Summary: Encodes an acyl-CoA binding protein that is localized to vesicles,and plasma membrane especially in epidermal cells of heart, torpedo and cotyledon stage embryos, cell wall of the seed coat. Northern blot analysis showed that the 1.4 kb ACBP1 mRNA was expressed in silique, root, stem, leaf and flower.
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Genomic context

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See ACBP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (21710170..21712614)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Binding of C18:1-CoA by ACYL-COA BINDING PROTEIN 1 (ACBP1) at the plasma membrane concomitantly leads to release and nuclear accumulation of the ERFVII transcription factor RELATED TO APETALA 2.12 (RAP2.12) which is central to the activation of anaerobic metabolism during stress.
Title: The ACBP1-RAP2.12 signalling hub: A new perspective on integrative signalling during hypoxia in plants.
ACBP1 was demonstrated to co-express and interact with SMO1-2.
Title: Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
ACBP1 appears to modulate the metabolism of two important lipid classes (fatty acids and sterols) influencing cellular signaling.
Title: Acyl-CoA-Binding Protein ACBP1 Modulates Sterol Synthesis during Embryogenesis.
AtACBP1 and AtACBP4 can protect lipids against Pb(II)-induced lipid peroxidation.
Title: Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confers Pb(II) accumulation in Brassica juncea roots.
ACBP2, which shows high (76.9%) conservation in amino acid homology to ACBP1, did not appear to be involved in the freezing response.
Title: Arabidopsis acyl-CoA-binding proteins ACBP1 and ACBP2 show different roles in freezing stress.
Results suggest that ACBP1 participates in ABA-mediated seed germination and seedling development.
Title: Arabidopsis acyl-CoA-binding protein ACBP1 participates in the regulation of seed germination and seedling development.
ACBP1 and ACBP2 are essential in lipid transfer during early embryogenesis in Arabidopsis.
Title: The Arabidopsis acbp1acbp2 double mutant lacking acyl-CoA-binding proteins ACBP1 and ACBP2 is embryo lethal.
ACBP1 overexpressors show alterations in phosphatidylcholine molecular species. Knockouts have enhanced freezing tolerance.
Title: Depletion of the membrane-associated acyl-coenzyme A-binding protein ACBP1 enhances the ability of cold acclimation in Arabidopsis.
When grown on Pb(II)-containing medium, transgenic Arabidopsis lines overexpressing ACBP1 were more tolerant to Pb(II)-induced stress than the wild type.
Title: Overexpression of membrane-associated acyl-CoA-binding protein ACBP1 enhances lead tolerance in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_124726.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables lead ion binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of seed germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seedling development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lead ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed dormancy process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: acyl-CoA binding protein 1

NP_200159.1

acyl-CoA binding protein 1 (ACBP1); CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

21710170..21712614

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124726.4 → NP_200159.1 acyl-CoA binding protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LB20, Q9LV02, Q9SM23, Q9ZRC2

UniProtKB/TrEMBL

A0A5S9YDL9

Conserved Domains (4) summary

cd00204
Location:221 → 324

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00887
Location:113 → 180

ACBP; Acyl CoA binding protein

pfam12796
Location:222 → 314

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:221 → 248

ANK; ANK repeat [structural motif]