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    CIA2 chloroplast import apparatus 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835824, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIA2
    Official Full Name
    chloroplast import apparatus 2
    Primary source
    TAIR:AT5G57180
    Locus tag
    AT5G57180
    See related
    Araport:AT5G57180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    chloroplast import apparatus 2; MUL3.13; MUL3_13
    Summary
    Transcription regulator responsible for specific upregulation of the translocon genes atToc33 and atToc75 in leaves. Involved in protein import into chloroplast.
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    Genomic context

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    See CIA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (23167774..23171025)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene DNA ligase IV Neighboring gene Tautomerase/MIF superfamily protein Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene ENTH/ANTH/VHS superfamily protein Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CIA2 coordinately up-regulates protein import and synthesis in leaf chloroplasts. Sun CW, et al. Plant Physiol, 2009 Jun. PMID 19386807, Free PMC Article
    2. Leaf-specific upregulation of chloroplast translocon genes by a CCT motif-containing protein, CIA 2. Sun CW, et al. Plant Cell, 2001 Sep. PMID 11549763, Free PMC Article
    3. CIA2 and CIA2-LIKE are required for optimal photosynthesis and stress responses in Arabidopsis thaliana. Gawroński P, et al. Plant J, 2021 Feb. PMID 33119927
    4. The Cytosolic Iron-Sulfur Cluster Assembly Protein MMS19 Regulates Transcriptional Gene Silencing, DNA Repair, and Flowering Time in Arabidopsis. Han YF, et al. PLoS One, 2015. PMID 26053632, Free PMC Article
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001037010.2
    NM_001345246.1
    NM_125100.4
    NM_180870.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein targeting to chloroplast IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    chloroplast import apparatus 2
    NP_001032087.1
    • chloroplast import apparatus 2 (CIA2); BEST Arabidopsis thaliana protein match is: CCT motif family protein (TAIR:AT4G25990.1); Has 102 Blast hits to 81 proteins in 17 species: Archae - 0; Bacteria - 0; Metazoa - 5; Fungi - 7; Plants - 54; Viruses - 0; Other Eukaryotes - 36 (source: NCBI BLink).
    NP_568852.2
    • chloroplast import apparatus 2 (CIA2); CONTAINS InterPro DOMAIN/s: CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: CCT motif family protein (TAIR:AT4G25990.1); Has 1820 Blast hits to 1799 proteins in 111 species: Archae - 0; Bacteria - 0; Metazoa - 6; Fungi - 7; Plants - 1718; Viruses - 0; Other Eukaryotes - 89 (source: NCBI BLink).
    NP_851201.1
    • chloroplast import apparatus 2 (CIA2); CONTAINS InterPro DOMAIN/s: CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: CCT motif family protein (TAIR:AT4G25990.2); Has 1391 Blast hits to 1370 proteins in 95 species: Archae - 0; Bacteria - 0; Metazoa - 5; Fungi - 7; Plants - 1340; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23167774..23171025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180870.2 → NP_851201.1  chloroplast import apparatus 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GBU3, F4KAK2
      Conserved Domains (1) summary
      pfam06203
      Location:383 → 419
      CCT; CCT motif

    2. NM_125100.4 → NP_568852.2  chloroplast import apparatus 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568852.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Y02, Q94JU7, Q9LU68
      UniProtKB/TrEMBL
      A0A178UDY1, A0A654GBU3
      Conserved Domains (1) summary
      pfam06203
      Location:383 → 426
      CCT; CCT motif

    3. NM_001037010.2 → NP_001032087.1  chloroplast import apparatus 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GBU3, F4KAK3

    4. NM_001345246.1 → NP_001332283.1  chloroplast import apparatus 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GBU3, F4KAK3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU68.1

    Gene LinkOut

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