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    LAC17 laccase 17 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836124, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAC17
    Official Full Name
    laccase 17
    Primary source
    TAIR:AT5G60020
    Locus tag
    AT5G60020
    See related
    Araport:AT5G60020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLAC17; laccase 17; MMN10.20; MMN10_20
    Summary
    LAC17 appears to have laccase activity based on enzyme assays performed using lac17 mutants. Notably, these mutants appear to have a reduced deposition of G lignin units. LAC17 is expressed in interfascicular fibers and likely contributes to lignin biosynthesis, and hence, cell wall biosynthesis, there.
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    Genomic context

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    See LAC17 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (24167996..24170462)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ferric reductase-like transmembrane component family protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene nuclear RNA polymerase C1 Neighboring gene BTB/POZ domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of LACCASE4 and 17 results in tissue-specific alterations to lignification of Arabidopsis thaliana stems. Berthet S, et al. Plant Cell, 2011 Mar. PMID 21447792, Free PMC Article
    2. Laccase is necessary and nonredundant with peroxidase for lignin polymerization during vascular development in Arabidopsis. Zhao Q, et al. Plant Cell, 2013 Oct. PMID 24143805, Free PMC Article
    3. Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development. Hoffmann N, et al. Plant Physiol, 2020 Oct. PMID 32699027, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development.
      Title: Laccases and Peroxidases Co-Localize in Lignified Secondary Cell Walls throughout Stem Development.
    2. Simultaneous disruption of LAC11 along with LAC4 and LAC17 causes severe plant growth arrest, narrower root diameter, indehiscent anthers, and vascular development arrest with lack of lignification.
      Title: Laccase is necessary and nonredundant with peroxidase for lignin polymerization during vascular development in Arabidopsis.
    3. Disruption of LAC17 affects plant development, vascular tissues, lignification, and saccharification efficiency to various extents.
      Title: Disruption of LACCASE4 and 17 results in tissue-specific alterations to lignification of Arabidopsis thaliana stems.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001345382.1
    NM_001345383.1
    NM_125395.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroquinone:oxygen oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laccase 17
    NP_200810.1
    • laccase 17 (LAC17); FUNCTIONS IN: laccase activity; INVOLVED IN: oxidation reduction, lignin catabolic process; LOCATED IN: endomembrane system, apoplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, C globular stage, petal differentiation and expansion stage, LP.12 twelve leaves visible; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Laccase (InterPro:IPR017761), Multicopper oxidase, type 2 (InterPro:IPR011706), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, copper-binding site (InterPro:IPR002355), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: laccase 2 (TAIR:AT2G29130.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24167996..24170462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125395.3 → NP_200810.1  laccase 17 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJD5
      UniProtKB/TrEMBL
      A0A178UD34, A0A5S9YFP1, A0A7G2FLI9
      Conserved Domains (1) summary
      TIGR03389
      Location:22 → 577
      laccase; plant

    2. NM_001345382.1 → NP_001330990.1  laccase 17 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCG5, A0A7G2FLI9

    3. NM_001345383.1 → NP_001330991.1  laccase 17 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCH1, A0A7G2FLI9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJD5.1

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