U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SAG101 senescence-associated gene 101 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831345, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SAG101
    Official Full Name
    senescence-associated gene 101
    Primary source
    TAIR:AT5G14930
    Locus tag
    AT5G14930
    See related
    Araport:AT5G14930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2G14.50; F2G14_50; senescence-associated gene 101
    Summary
    encodes an acyl hydrolase involved in senescence .
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SAG101 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (4828499..4830982)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene helicase associated (HA2) domain-containing protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Gibberellin-regulated family protein Neighboring gene Major facilitator superfamily protein Neighboring gene golgi alpha-mannosidase II

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A gene encoding an acyl hydrolase is involved in leaf senescence in Arabidopsis. He Y, et al. Plant Cell, 2002 Apr. PMID 11971136, Free PMC Article
    2. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Sun X, et al. Nat Commun, 2021 Jun 7. PMID 34099661, Free PMC Article
    3. Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101. Wagner S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Feb 1. PMID 21301097, Free PMC Article
    4. A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors. Lapin D, et al. Plant Cell, 2019 Oct. PMID 31311833, Free PMC Article
    5. Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity. Wagner S, et al. Cell Host Microbe, 2013 Dec 11. PMID 24331460

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
      Title: Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
    2. AtEDS1-AtSAG101 functions together with N REQUIRED GENE1 (AtNRG1) coiled-coil domain helper NLRs as a coevolved TNL cell death-signaling module.
      Title: A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.
    3. Mutational analysis of the EDS1-SAG101 heterodimer and a derived EDS1-PAD4 structural model shows that EDS1 signals within mutually exclusive heterocomplexes.
      Title: Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity.
    4. SAG101 is required for R-mediated resistance to TCV, thus implicating a role for the ternary complex in this defense response.
      Title: SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.
    5. Data show that EDS1 interacts in vivo with another protein, SENESCENCE-ASSOCIATED GENE101 (SAG101), and that interactions of EDS1 and its signaling partners are important for plant defense signal relay.
      Title: Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001085116.1
    NM_121497.5
    NM_180708.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    senescence-associated gene 101
    NP_001078585.1
    • senescence-associated gene 101 (SAG101); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G52430.1); Has 224 Blast hits to 223 proteins in 35 species: Archae - 0; Bacteria - 4; Metazoa - 0; Fungi - 0; Plants - 205; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).
    NP_568307.3
    • senescence-associated gene 101 (SAG101); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G52430.1); Has 536 Blast hits to 436 proteins in 38 species: Archae - 0; Bacteria - 6; Metazoa - 0; Fungi - 0; Plants - 513; Viruses - 0; Other Eukaryotes - 17 (source: NCBI BLink).
    NP_851039.1
    • senescence-associated gene 101 (SAG101); Has 22 Blast hits to 22 proteins in 4 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 22; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4828499..4830982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121497.5 → NP_568307.3  senescence-associated gene 101 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568307.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K898, Q4F883, Q8LCZ8, Q9LFR2
      UniProtKB/TrEMBL
      A0A5S9Y6F5
      Conserved Domains (1) summary
      cl21494
      Location:112 → 202
      Abhydrolase; alpha/beta hydrolases

    2. NM_001085116.1 → NP_001078585.1  senescence-associated gene 101 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MS15
      Conserved Domains (1) summary
      cl21494
      Location:112 → 202
      Abhydrolase; alpha/beta hydrolases

    3. NM_180708.2 → NP_851039.1  senescence-associated gene 101 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UL70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4F883.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.