TSL Protein kinase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TSL
Official Full Name: Protein kinase superfamily protein
Primary source: TAIR:AT5G20930
Locus tag: AT5G20930
See related: Araport:AT5G20930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F22D1.100; F22D1_100; PROTEIN KINASE TSL; TOUSLED
Summary: Nuclear serine/threonine protein kinase that requires a coiled-coil region for oligomerization and catalytic activity. Required for leaf and flower development. Expression localized to the developing style by stage 13.
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Genomic context

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See TSL in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 16

Sequence:: Chromosome: 5; NC_003076.8 (7097868..7103206)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest a possible role for TSL phosphorylation in the specific regulation of exogenous and antiviral RNA silencing in Arabidopsis and identify TSL as an intrinsic regulator of RNA interference.
Title: The protein kinase TOUSLED facilitates RNAi in Arabidopsis.
Our results provide direct evidence for a crucial role of the TOUSLED protein kinase in the maintenance of transcriptional gene silencing in some genomic regions in a DNA-methylation-independent manner in Arabidopsis.
Title: The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122101.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Protein kinase superfamily protein

NP_568405.1

TOUSLED (TSL); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: nucleus, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora3 (TAIR:AT2G45490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

7097868..7103206

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122101.2 → NP_568405.1 Protein kinase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568405.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39238, Q8LPL1

UniProtKB/TrEMBL

A0A178UBG5, A0A5S9Y610, A0A7G2FE35

Conserved Domains (1) summary

cd13990
Location:408 → 682

STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase