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    ZIP4 Clathrin adaptor complexes medium subunit family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842113, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZIP4
    Official Full Name
    Clathrin adaptor complexes medium subunit family protein
    Primary source
    TAIR:AT1G56590
    Locus tag
    AT1G56590
    See related
    Araport:AT1G56590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adaptor protein-3 mu-adaptin; AP3M; F25P12.96; F25P12_96; ZIG SUPPRESSOR 4
    Summary
    Involved in vesicle trafficking between the trans -Golgi network and vacuoles.
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    Genomic context

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    See ZIP4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (21201948..21204856, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Plant neutral invertase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene plant/protein (Protein of unknown function, DUF538) Neighboring gene galactinol synthase 2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development. Kansup J, et al. J Exp Bot, 2013 Dec. PMID 24098050, Free PMC Article
    2. ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles. Niihama M, et al. Plant Cell Physiol, 2009 Dec. PMID 19884248
    3. The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization. Feng QN, et al. Plant Physiol, 2018 May. PMID 29523712, Free PMC Article
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for AP-3 in pollen tube growth.
      Title: The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization.
    2. At1g56590(AP-3micro) positively regulates the abscisic acid responses independently of AGB1 in seed germination, while AP-3micro does require AGB1 to regulate abscisic acid responses during post-germination growth.
      Title: The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development.
    3. zip4 is a loss-of-function mutant of a putative ortholog of the yeast AP-3 mu subunit, and is involved in protein trafficking between the trans-Golgi network and vacuoles.
      Title: ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104536.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein targeting to vacuole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Clathrin adaptor complexes medium subunit family protein
    NP_176052.3
    • ZIG SUPPRESSOR 4 (ZIP4); INVOLVED IN: intracellular protein transport, gravitropism, protein targeting to vacuole; LOCATED IN: clathrin vesicle coat, clathrin adaptor complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 1984 Blast hits to 1954 proteins in 323 species: Archae - 0; Bacteria - 0; Metazoa - 926; Fungi - 482; Plants - 226; Viruses - 0; Other Eukaryotes - 350 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21201948..21204856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104536.5 → NP_176052.3  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176052.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I562, Q9FXB1
      UniProtKB/TrEMBL
      A0A5S9WQ97, A0A654EP65
      Conserved Domains (2) summary
      cd09252
      Location:167 → 414
      AP-3_Mu3_Cterm; C-terminal domain of medium Mu3 subunit in adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 142
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I562.1

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