LTB4R2 leukotriene B4 receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LTB4R2provided by HGNC
Official Full Name: leukotriene B4 receptor 2provided by HGNC
Primary source: HGNC:HGNC:19260
See related: Ensembl:ENSG00000213906 MIM:605773; AllianceGenome:HGNC:19260
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BLT2; NOP9; BLTR2; JULF2; KPG_004; LTB4-R2; LTB4-R 2
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in skin (RPKM 12.7), spleen (RPKM 9.3) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (24310140..24312038)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (18508483..18510381)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24779346..24781244)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.
Title: LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.
[Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia].
Title: [Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia].
Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma.
Title: Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma.
Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
Title: Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
Prognostic and immunological value of LTB4R in pan-cancer.
Title: Prognostic and immunological value of LTB4R in pan-cancer.
The critical roles of BLT2 on the functions of bronchial epithelial cells.
Title: Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells.
Authors found that BLT2, a cell surface GPCR for leukotriene B4 and 12hydroxyeicosatetraenoic acid, is highly upregulated in KRAS mutant LOVO and SW480 colorectal cancer cells and plays critical roles in mediating proliferation through activation of phosphatidylinositol 3kinase (PI3K)/protein kinase B (Akt) and subsequent upregulation of cyclin D1.
Title: Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
Our analysis identified six significant (Sidak corrected P < 0.05) depression-associated differentially methylated regions (DMRs); the top-ranked DMR was located in exon 1 of the LTB4R2 gene (Sidak corrected P = 1.27 x 10-14).
Title: DNA methylation and inflammation marker profiles associated with a history of depression.
In a group of 545 breast cancer patients with metastasis, authors observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup.
Title: BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer.
BLT2 gene polymorphism (D196G) enhances ligand sensitivity, thereby increasing cell motility in response to low-dose ligand stimulation.
Title: Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in leukotriene signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: leukotriene B4 receptor 2

Names: LTB4 receptor JULF2; leukotriene B4 receptor BLT2; seven transmembrane receptor BLTR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164692.3 → NP_001158164.1 leukotriene B4 receptor 2

See identical proteins and their annotated locations for NP_001158164.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK304169, AL096870, BC038437, DC408599

Consensus CDS

CCDS9625.2

UniProtKB/Swiss-Prot

Q5KU28, Q9NPC1, Q9NPE5

UniProtKB/TrEMBL

B4E292

Related

ENSP00000445772.1, ENST00000543919.1

Conserved Domains (2) summary

cd14964
Location:23 → 47

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:21 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_019839.5 → NP_062813.2 leukotriene B4 receptor 2

See identical proteins and their annotated locations for NP_062813.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AB032558, AK304169, AL096870, DC408599

Consensus CDS

CCDS9625.2

UniProtKB/Swiss-Prot

Q5KU28, Q9NPC1, Q9NPE5

UniProtKB/TrEMBL

B4E292

Related

ENSP00000433290.1, ENST00000533293.2

Conserved Domains (2) summary

cd14964
Location:23 → 47

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:21 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

24310140..24312038

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

NW_018654722.1 Reference GRCh38.p14 PATCHES

Range

611118..613016

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

18508483..18510381

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001164693.1: Suppressed sequence

Description

NM_001164693.1: This RefSeq was permanently suppressed because there is not sufficient data to support splicing of an intron with non-consensus splice sites in the CDS.