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    Tmem249 transmembrane protein 249 [ Mus musculus (house mouse) ]

    Gene ID: 666504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem249provided by MGI
    Official Full Name
    transmembrane protein 249provided by MGI
    Primary source
    MGI:MGI:3647471
    See related
    Ensembl:ENSMUSG00000116376 AllianceGenome:MGI:3647471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm8140; Catsperq; EG666504
    Summary
    Located in sperm principal piece. Part of CatSper complex. Orthologous to human TMEM249 (transmembrane protein 249). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 85.3) See more
    Orthologs
    human all
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    Genomic context

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    See Tmem249 in Genome Data Viewer
    Location:
    15 D3; 15 36.03 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76417411..76419197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76533211..76534997, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene scratch family zinc finger 1 Neighboring gene predicted gene, 46533 Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene solute carrier protein 52, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Huang X, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37725640, Free PMC Article
    2. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Huang X, et al. bioRxiv, 2023 Mar 17. PMID 36993167, Free PMC Article
    3. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit TMEM249
    Names
    Catsper theta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378247.1 → NP_001365176.1  cation channel sperm-associated auxiliary subunit TMEM249

      Status: VALIDATED

      Source sequence(s)
      AC157566
      UniProtKB/Swiss-Prot
      A0A2R8VHF7
      Related
      ENSMUSP00000155040.2, ENSMUST00000230604.2
      Conserved Domains (1) summary
      pfam15158
      Location:1 → 144
      DUF4579; Domain of unknown function (DUF4579)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76417411..76419197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159542.1 → XP_036015435.1  cation channel sperm-associated auxiliary subunit TMEM249 isoform X1

      UniProtKB/TrEMBL
      A0AAQ4VMS7
      Conserved Domains (1) summary
      pfam15158
      Location:7 → 167
      DUF4579; Domain of unknown function (DUF4579)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2R8VHF7.1 GenPept UniProtKB/Swiss-Prot:A0A2R8VHF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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