Rsph3a radial spoke 3A homolog (Chlamydomonas) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsph3aprovided by MGI
Official Full Name: radial spoke 3A homolog (Chlamydomonas)provided by MGI
Primary source: MGI:MGI:1914082
See related: Ensembl:ENSMUSG00000073471 AllianceGenome:MGI:1914082
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rshl2; Rshl2a; 1700012G05Rik; 4930524H12Rik
Summary: Predicted to be located in 9+2 motile cilium. Predicted to be part of radial spoke head. Predicted to be active in cilium. Is expressed in several structures, including brain; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 32. Orthologous to human RSPH3 (radial spoke head 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 166.6), ovary adult (RPKM 29.7) and 20 other tissues See more
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Genomic context

Location:: 17 A1; 17 4.82 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (8164446..8198388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (7945614..7979556)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that RSP3 is a nucleocytoplasmic shuttling protein and plays an essential role in neurogenesis.
Title: The mouse radial spoke protein 3 is a nucleocytoplasmic shuttling protein that promotes neurogenesis.
The subcellular localization and function of mammalian RSP3 in mammalian cells and developing CNS.
Title: Subcellular localization and function of mouse radial spoke protein 3 in mammalian cells and central nervous system.
Rshl2 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rshl2a (e-PCR), detects polymorphism
- UniSTS:498253

RH125119 (e-PCR)
- UniSTS:161941

NoName (e-PCR)
- UniSTS:491464

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
part_of radial spoke head	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: radial spoke head protein 3 homolog A

Names: A-kinase anchor protein RSPH3A; radial spoke head-like protein 2A; radial spokehead-like 2; radial spokehead-like 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.