Kctd8 potassium channel tetramerisation domain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd8provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 8provided by MGI
Primary source: MGI:MGI:2443804
See related: Ensembl:ENSMUSG00000037653 AllianceGenome:MGI:2443804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730087N02Rik
Summary: Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Part of receptor complex. Is active in postsynapse and presynaptic active zone membrane. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human KCTD8 (potassium channel tetramerization domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 7.0), CNS E18 (RPKM 4.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 37.01 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (69266628..69499052, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (69109285..69341709, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in Habenula Cholinergic Neurons.
Title: KCTD8 and KCTD12 Facilitate Axonal Expression of GABA(B) Receptors in Habenula Cholinergic Neurons.
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Title: GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Title: Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125601 (e-PCR)
- UniSTS:162415

BB389606 (e-PCR)
- UniSTS:207796

C85052 (e-PCR)
- UniSTS:179180

NoName (e-PCR)
- UniSTS:492538

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.