Itga1 integrin alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga1provided by MGI
Official Full Name: integrin alpha 1provided by MGI
Primary source: MGI:MGI:96599
See related: Ensembl:ENSMUSG00000042284 AllianceGenome:MGI:96599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vla1; CD49A; E130012M19Rik
Summary: Predicted to enable collagen binding activity involved in cell-matrix adhesion; integrin binding activity; and protein phosphatase binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway. Acts upstream of or within cell adhesion; cellular extravasation; and neutrophil chemotaxis. Located in basal part of cell and external side of plasma membrane. Is expressed in blood vessel endothelium; embryo mesenchyme; intestine smooth muscle; and lung. Used to study type 1 diabetes mellitus. Orthologous to human ITGA1 (integrin subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 14.3), lung adult (RPKM 11.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 64.61 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (115094615..115238500, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (114958079..115101964, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VLA-1 Binding to Collagen IV Controls Effector T Cell Suppression by Myeloid-Derived Suppressor Cells in the Splenic Red Pulp.
Title: VLA-1 Binding to Collagen IV Controls Effector T Cell Suppression by Myeloid-Derived Suppressor Cells in the Splenic Red Pulp.
Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon.
Title: Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon.
TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.
Title: T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.
Sema7A, as an inflammation regulator in CVB3-induced Viral myocarditis, might interact with alpha1beta1-integrin in macrophages to enhance the inflammatory response and aggravate disease severity.
Title: Semaphorin7A aggravates coxsackievirusB3-induced viral myocarditis by increasing α1β1-integrin macrophages and subsequent enhanced inflammatory response.
the cross-talk between SFRP4, integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells.
Title: Cross-talk of SFRP4, integrin α1β1, and Notch1 inhibits cardiac differentiation of P19CL6 cells.
Data show that in the absence of Langerhans Cells, CD49a(+) liver NK cells display an inappropriately proinflammatory phenotype that results in increased local skin inflammation.
Title: Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation.
The decrease in hepatic lipid accumulation in HF-fed itga1(-/-) mice was associated with altered free fatty acid metabolism. These studies establish a role for integrin signaling in facilitating hepatic insulin action
Title: Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance.
a crosstalk between integrin alpha1beta1 and TbetaRII is essential for TbetaRII-mediated SMAD activation and fibrotic signaling pathways
Title: Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Synthesis and modeling of linear and cyclic KTS-containing peptides is described that leads to their use as inhibitors of integrin alpha1beta1/alpha2beta1-mediated adhesion and other antiangiogenetic activity in human serum.
Title: Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity.
Data indicate that integrin alpha1beta1 is a key participant in chondrocyte transduction of a hypo-osmotic stress.
Title: Integrin α1β1 participates in chondrocyte transduction of osmotic stress.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC141158P1 (e-PCR)
- UniSTS:270996

RH124904 (e-PCR)
- UniSTS:161726

AI852218 (e-PCR)
- UniSTS:164542

Itga1 (e-PCR), detects polymorphism
- UniSTS:143608

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding involved in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
enables collagen binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of integrin alpha1-beta1 complex	IEA Inferred from Electronic Annotation more info
part_of integrin alpha1-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin alpha-1

Names: CD49 antigen-like family member A; VLA-1; laminin and collagen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.