Htr1a 5-hydroxytryptamine (serotonin) receptor 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr1aprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Aprovided by MGI
Primary source: MGI:MGI:96273
See related: Ensembl:ENSMUSG00000021721 AllianceGenome:MGI:96273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpcr18
Summary: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; regulation of serotonin secretion; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in GABA-ergic synapse; dendrite; and presynaptic membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.92 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (105580040..105584630)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (105443693..105448133)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice.
Title: Astrocytic 5-HT(1A) receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice.
Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension.
Title: Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension.
Altered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice.
Title: Altered brain serotonin 5-HT(1A) receptor expression and function in juvenile Fmr1 knockout mice.
5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice.
Title: 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice.
Sex Differences in Serotonin 5-HT 1A Receptor Responses to Repeated Restraint Stress in Adult Male and Female Rats.
Title: Sex Differences in Serotonin 5-HT 1A Receptor Responses to Repeated Restraint Stress in Adult Male and Female Rats.
Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice.
Title: Possible role of transcriptional regulation of 5-HT(1A) receptor in the midbrain on unadaptation to stress in mice.
Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice.
Title: Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice.
Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression.
Title: Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression.
Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells.
Title: Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells.
Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.
Title: Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (152)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr1a (e-PCR), detects polymorphism
- UniSTS:143413

PMC166422P2 (e-PCR)
- UniSTS:271595

BF390878 (e-PCR)
- UniSTS:249593

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables Gi/o-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor-receptor interaction	IEA Inferred from Electronic Annotation more info
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info
enables serotonin binding	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in serotonin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon hillock	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1A

Names: 5-HT-1A; 5-HT1A receptor; G-protein coupled receptor 18; serotonin receptor 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008308.5 → NP_032334.2 5-hydroxytryptamine receptor 1A

See identical proteins and their annotated locations for NP_032334.2

Status: VALIDATED

Source sequence(s)

AC114573

Consensus CDS

CCDS26756.1

UniProtKB/Swiss-Prot

Q60956, Q61617, Q64264, Q8BGS4

UniProtKB/TrEMBL

Q8BZP1

Related

ENSMUSP00000022235.5, ENSMUST00000022235.6

Conserved Domains (2) summary

pfam00001
Location:53 → 400

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:48 → 169

7tm_4; Olfactory receptor